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ITMO Genetics, genomics
& bioinformatics
The impact of genetics, genomics &
bioinformatics on personalized medicine
Thierry Grange, CNRS
ARIIS
CIRAD
EFS
ARIIS
CIRAD
EFS
CEA
CHRU
CNRS
FONDATION MERIEUX
CEA
CHRU
CNRS
FONDATION MERIEUX
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
IRD
IRBA
IRD
IRBA
IRSN
UNICANCER
IRSN
UNICANCER
1
ITMO Genetics, genomics
& bioinformatics
Coordination of the action of the French
research institutions in Genetics,
Genomics & Bioinformatics
ARIIS
CIRAD
EFS
ARIIS
CIRAD
EFS
CEA
CHRU
CNRS
FONDATION MERIEUX
CEA
CHRU
CNRS
FONDATION MERIEUX
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
IRD
IRBA
IRD
IRBA
IRSN
UNICANCER
IRSN
UNICANCER
2
Major strategic priorities
• Next Generation Sequencing & Bioinformatics:
Integrating Big Data with Modeling
• Epigenetics & Regulation of Gene Expression:
Interactions between genomes and environment
• Evolution of genomes and populations
• Individual genomes and personalized medicine
ARIIS
CIRAD
EFS
CEA
CHRU
CNRS
FONDATION MERIEUX
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
IRD
IRBA
IRSN
UNICANCER
3
Key transversal question
• Understanding the relationship between
genotype and phenotype
ARIIS
CIRAD
EFS
CEA
CHRU
CNRS
FONDATION MERIEUX
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
IRD
IRBA
IRSN
UNICANCER
4
ITMO Genetics, genomics
& bioinformatics
How genetics, genomics and
bioinformatics can contribute to
personalized medicine?
ARIIS
CIRAD
EFS
ARIIS
CIRAD
EFS
CEA
CHRU
CNRS
FONDATION MERIEUX
CEA
CHRU
CNRS
FONDATION MERIEUX
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
IRD
IRBA
IRD
IRBA
IRSN
UNICANCER
IRSN
UNICANCER
5
Interpreting personal genomes
• Sequencing personal genomes is becoming
technically and financially within reach
• How can this information be used to adapt
treatments to the individual genetic make-up?
• There is a need to better understand the
relationship between genome sequences and
personal/population phenotypes
ARIIS
CIRAD
EFS
CEA
CHRU
CNRS
FONDATION MERIEUX
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
IRD
IRBA
IRSN
UNICANCER
6
Today’s speakers
Thierry Frebourg, Inserm
CHU Rouen
ARIIS
CIRAD
EFS
CEA
CHRU
CNRS
FONDATION MERIEUX
Lluis Quintana-Murci, CNRS
Institut Pasteur
CPU
INRA
INRIA
INSERM
INSTITUT PASTEUR
INERIS
INSTITUT CURIE
INSTITUT MINES-TELECOM
IRD
IRBA
IRSN
UNICANCER
7