NovaMin and Gingivitis
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Transcript NovaMin and Gingivitis
NovaMin
What is NovaMin®?
A “high-tech” active ingredient used in the
most innovative professional dental products.
Material Description
NovaMin is a breakthrough
remineralization technology.
A tasteless white powder form.
NovaMin amplifies the natural
protective and repair mechanisms
for teeth and gums.
Extensively proven in clinical and
scientific studies at leading dental
schools around the world.
Technical Breakdown
Comprised of calcium,
sodium, phosphorous
and silica, all natural
elements found in the
body
Chemical name is Calcium Sodium
Phosphosilicate
NovaMin is recognized as the only man
made ingredient that directly leads to the
formation of new tooth mineral
(HCA)
What Does NovaMin® Do?
Repairs Surface Lesions
Forms biomimetic HCA on
tooth dentin and enamel
surface lesions
Reduces Sensitivity
Occludes dentin tubules:
forms a protective
biomimetic HCA layer.
Improves Gingival Health
Antimicrobial properties &
Anti-inflammatory
properties reduce gingivitis.
The NovaMin® Solution
Hard Tissue Benefits
The NovaMin® Solution
Soft Tissue Benefits
NovaMin: How it Starts
NovaMin is also called “calcium
sodium phosphosilicate”.
It is made from elements
naturally found in healthy teeth
and bones:
Calcium ( ), Phosphorus ( ),
Sodium ( ) and Silicon ( )
Step 1: pH Elevation
+H2O
NovaMin reacts with
saliva. Na+ ions release,
elevating pH into the
range essential for
HCA formation.
8.0-8.5
pH
Step 2: Mineral Release
Ca2+ and P5+
ions are
released,
saturating saliva
with the ions
needed for
remineralization.
Ca2+
P5+
Step 3: Bacterial Kill
Na+ and Ca2+ ions
overwhelm bacterial
cells’ ability to regulate
their water content,
leading to lysis (cell
death) of harmful
bacteria in the mouth.
F. Nucleatum
S. Mutans
A.Naeslundii
-99.99%
S. Sanguis
-99.999%
-99.999%
-99.99999%
Tooth Mineral Structure - Hydroxy-carbonate Apatite (“HCA”)
Step 4: Crystal Building
Enamel Crystal Prism
Demineralized
lesions attract
Ca2+ and P5+ ions,
where they build
new HCA crystal to
remineralize the
defect from the
bottom up.
Tooth Mineral Structure - Hydroxy-carbonate Apatite (“HCA”)
Step 5: Time Release
Enamel Crystal Prism
NovaMin particles
adhere to tooth
surfaces for up to 7
days, continuing to
release Na+, Ca2+, and
P5+ ions to maintain
elevated pH at the
tooth surface and
foster remineralization
over time.
Remineralization of Dentin & Enamel
In-vitro Study – In-Situ Models
After Treatment
Before Treatment
Surface Lesion
In-vitro
Surface Abrasion
In-Situ
Exposed Dentin
In-vitro
NovaMin Product Focuses
• Sensitivity:
Faster & better results
Addresses symptom, not cause.
• Gingivitis:
Faster results
Less controversial ingredient
• Root Caries/Remineralization:
Adult caries predominantly related to hyposalivation.
NovaMin directly addresses this etiology.
NovaMin & Sensitivity
NovaMin Therapy Paste Results
Clinical Results Vs. Placebo
VAS Score
Averaged Across Methods
8
7
6
5
4
3
2
1
0
NovaMin
Control
p<0.001
Baseline
1 week
2 weeks
3 weeks
4 weeks
NovaMin & Sensitivity
NovaMin Therapy Paste Results
Clinical Results Vs. Other Actives
NovaMin Vs. Potassium Nitrate
8.0
VAS Water
p<0.05
6.0
Potassium Nitrate
4.0
Stannous Fluoride
NovaMin
2.0
0.0
0
2
4
Weeks
12
NovaMin vs. Fluoride
Remineralization of Dentin
NTI-UCSF In-vitro Study – Dentin Remin/Demin Model
1400
Product Tested
1200
7.5% NM/1100 ppm MFP
1
800
7.5% NM
2
600
Company CR 5000 ppm NaF 3
1000
Delta Z
Code
400
Company CG 1.1 ppm MFP
4
0% NM/O ppm F
5
200
0
1
2
3
Product Code Tested
4
5
NovaMin and Gingivitis
Anti-Microbial Properties
Log Reduction in Microbial CFU's - 2 Minute Exposure to 1:3 Dilution
Bacterial Species
0
S mutans
S sanguis
F nucleatum
A naeslundii
-1
Log Reduction in Viability
-2
-3
-4
-5
-6
-7
-8
-9
NovaMin Non Aqueous Toothpaste
NovaMin Powder
Colgate Red Box Toothpaste
NovaMin and Gingivitis
Pilot Clinical Study – Gingival Bleeding Index
Summary of Gingival Index Findings
1.4
p<0.01
1.2
GBI
1
0.8
-59%
0.6
NovaMin
Placebo
0.4
0.2
0
baseline
6 week
Time Period
NovaMin and Gingivitis
Pilot Clinical Study – Plaque Index
Summary of Plaque Index Findings
1.8
1.6
p<0.025
1.4
PLI
1.2
1
NovaMin
Placebo
0.8
0.6
0.4
0.2
0
baseline
6 week
Time Period
NovaMin/Fluoride Enamel
Remineralization
In-vitro Study – Remin/Demin Model
Surface Lesion
~ 100µm
Sound Enamel
Demineralized
Untreated Sample
Sound Enamel
Fluoride Dentifrice
Treated Sample
Sound Enamel
NovaMin Dentifrice + F
Treated Sample
NovaMin/Fluoride Enamel
Remineralization
In-vitro Study – Remin/Demin Model
Lesion Area
Lesion Area (sq.
microns x1000)
40
p<0.001
30
-30%
-45%
20
10
0
Demin
F paste
Treatment Group
F + NovaMin