Transcript 56email lupin - Prof. Palpu Pushpangadan

R&D Activities
National Botanical Research
Institute, Lucknow
(Herbal Technology)
Dr. P. Pushpangadan
Director
National Botanical Research Institute,
Lucknow
National Botanical Research Institute, Lucknow
A premier plant research
center of India under the
umbrella of CSIR by
undertaking both basic and
applied research in various
aspects of plant sciences for
the
conservation
and
sustainable utilization of
plant genetic resources for
human
welfare
and
sustainable.
Research Council
Management Council
Economic Botany
Information Service
Plant Biodiveristy and
Conservation Biology
Botanic garden and
Floriculture
(Dr. P. Pushpangadan)
Information Liaison and
Common Facilities
Planning and
Coordination
Biotechnology and
Plant Physiology
Experimental
Research stations
Molecular Biology and
Genetic Engineering
Biomass Biology and
Environmental Sciences
House Keeping
Auxilliary
Genetics & Plant Breeding
and Agrotechnology Microbiology &
Plant Pathology
Natural Product
Development
Mission
The mission of the National
Botanical Research Institute is:
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To act as a premier plant research
centre of India under the umbrella of
CSIR by undertaking both basic and
applied research in various aspects of
plant sciences for the conservation and
sustainable utilization of plant genetic
resources for human welfare and
sustainable development.
Vision
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To be a premier national and international centre
on plant science research and development in
the areas of plant biodiversity, conservation &
sustainable utilization of non-crop and wild Plant
Genetic Resources (PGR), bioprospecting,
biofuels, bioinformatics and plant biotechnology.
To be a prime catalyst in conversion of plant
wealth into economic wealth in an ecologically
sound and economically rewarding manner.
To develop as a national referral centre for all
knowledgebase related to plant biodiversity.
Mandate
To undertake both basic and applied research on
plant
sciences
in
taxonomy
(including
biosystematics
and
molecular
taxonomy),
conservation
biology,
pharmacognosy,
ethnopharmacology,
biomass
biology,
environmental sciences, microbiology, plant
biotechnology (tissue culture and molecular
biology including genetic engineering), plant
physiology, Phytochemistry, genetics and plant
breeding, floriculture and bioinformatics of the
non-crop and wild plant genetic resources of
India.
MAJOR R & D PROGRAMMES
Biodiversity research by inventorying, monitoring,
assessment, conservation and sustainable utilization of
plant genetic resources of India with special focus on
medicinal, aromatic, dye
Bioprospecting for search of commercially valuable
genes, biodynamic compounds and development of
scientifically validated, value-added and standardized
noval plant products-herbal drugs, pharmaceuticals,
nutraceuticals and cosmaceuticals.
Biomass biology including biopesticides, biofuels and
petroleum alternatives and environmental sciences
including phytoremediation and abatment of terrestrial
and aquatic pollution including studies on greenhouse gas
emission.
MAJOR R & D PROGRAMMES
Biotechnology (biotech process/products) including
trans-disciplinary studies on molecular biology and
genetic engineering for development of transgenic
plants.
Genetics, plant breeding and agrotechnology
Selection and genetic enhancement for development of
new promising varieties of economically important
non-crop plants.
Bioinformatics
by
developing
computerized/
electronic databases on Indian plants with special
focus on medicinal, aromatic, dyes, gum and tannin
yielding plants and products and applications of IT in
plant science research.
Herbal products developed
by NBRI
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Herbal fermented drink
Herbal Soft Drink
Herbal lipstick (Luvstik)
Herbal Gulal
Nutraceuticals products
Neem products
Organic cultivation using microbial
technology/ vermiculture etc.
Products in pipeline
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Wound healing ointment
Anti-ulcer formulation
Anti-diarrhoreal syrup
Anti-oxidant formulation
Aims and objectives of
Pharmacognosy & Ethnopharmacology
Division
 To carry out detailed pharmacognostic studies which
includes correct taxonomic identification of plants
and it parts, macro- and microscopical details and
histochemical analysis of the plant parts used as
medicine. The SEM studies are also under taken for
the identification/authentication of those commercial
samples, which are available in broken or small
pieces.
 To develop chemical markers for the identification,
quality and batch-to-batch consistency of herbal
drugs with the help of HPTLC, HPLC, GLC & DNA
finger printings etc.
Contd..
 To develop physico-chemical standards of crude as well
as finished herbal drugs/products.
 To detect the microbial contamination including the
detection of mycotoxins in herbal drugs (raw as well as
finished) in accordance with the latest WHO guidelines.
 To estimate concentration of heavy metals and
pesticide residue in herbal drugs as per WHO
guidelines.
 A small animal house and a pharmacology lab has also
been established to cover the safety aspects or toxicity
and other pharmacological evaluation of herbal
products.
 Besides, the survey work for collection of authentic
samples i. e. resource survey, market surveillance,
shelf-life studies, seasonal and ecological variations,
effect of ‘Shodhan Sanskar’ and scientific validation of
ethnobotanical claims are some of the important
activities of the group.
The Current Innovation
Herbal slimming/ anti
obesity agent
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Based on certain traditional leads we have
screened a large number of medicinal
plants and identified the potential ones.
Further screening narrowed down to the
most promising ones.
These were then subjected to detailed
chemical
and
pharmacological
standardization including the various
ecotypes of the species selected.
Contd…
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Activity guided extraction(s) and their
various combination their of were made
and evaluated pharmacologically.
Various combinations were made with the
help of the best Ayurveda experts.
The
final
formulation
(including
standardized extracts) was made by a
team of scientists drawn from Ayurveda,
Pharmacognosy,
Medicinal
chemistry,
Pharmacology and Pharmacy.
Formulation
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Contain 4 medicinal plants.
The extracts of the selected
plants were lyophilized and used
in the preparation of the final
formulation.
Chemical evaluation
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Some
chemical
moieties/marker
compounds present in the chosen plants
were identified.
Chemo/ fingerprint profiling of the extracts
were done using modern sophisticated
techniques like HPTLC/ HPLC.
Profiling of the final product was also
recorded.
Pharmacological evaluation
S D Rats (over weight) were used in
experimentation
Monitored:
Body weight profile
Biochemical estimations
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Triglycerides
Cholestrol
Phosphilipids
Pharmacological findings
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Over weight was significantly reverted
back.
Significant reduction in
PHOSPOLIPIDS and CHOLESTROL
TRIGLYCERIDE level was maintained in
the treated groups.
Toxicological evaluation
Given orally does not shown any
gross abnormality or mortality in
acute toxicity studies
IPR
It is protected by
patenting in
US and PCT.
Contact
Dr. P. Pushpangadan
Director
National Botanical Research Institute,
Rana Pratap Marg, Post Box 436
Lucknow-226 001 (U.P.) India
Ph.: 0522-2205848, 2205839
Fax: 0522-2205836, 2205839
email: [email protected]