Transcript NANOTISSUE ENGINEERING RESEARCH In vitro: Tissue

School of Biomedical Engineering, Science & Health Systems
NANOTISSUE ENGINEERING RESEARCH
Cellular Tissue Engineering: Primary Target Tissues / Organs
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Cardiovascular Tissues:
• Blood Vessels
• Heart
Neural Tissues:
• Brain
• Peripheral Nerves
Endocrine Tissues:
• Pancreas
• Adrenal
Tumor Spheroids:
• Breast Cancer
 Angiogenesis
 MDR
Faculty: Peter I. Lelkes, PhD, Drexel University.
E-mail: [email protected]
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V 1.0 SD [040227]
School of Biomedical Engineering, Science & Health Systems
NANOTISSUE ENGINEERING RESEARCH
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In vitro: Tissue Engineering
Macro- / Micro-scale for Individual Components:
• Cells Cell Aggregates.
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• Scaffolds: Fibrous, Textured.
50 nm
In vivo: NanoScale Cellular Action:
• Cell-ECM communications are on the nano-scale.
Faculty: Peter I. Lelkes, PhD, Drexel University.
E-mail: [email protected]
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School of Biomedical Engineering, Science & Health Systems
NANOTISSUE ENGINEERING RESEARCH
Induction of Myocyte Differentiation By Electrical Stimulation
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• Conductivity: Carbon Nanoparticles
• Cells: Cardiac Myocyte Precursors
Faculty: Peter I. Lelkes, PhD, P. Bidez, L. Venancio, Drexel University; A. MacDiarmid, PhD, University of Pennsylvania.
E-mail: [email protected]
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School of Biomedical Engineering, Science & Health Systems
NANOTISSUE ENGINEERING RESEARCH
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Nanotechnology-based Elastomeric Vascular Graft
• Composition:
–Substrate : polydimethylsiloxane (PDMS) (Sylgard® 184)
–Self-assembled monolayer : 3-(triethoxysilyl)propylsuccinic anhydride (TESPSA)
(carboxylic acid terminated);
–Peptide: RGD
• Texture: Smooth
Width = 18 m
Depth = 500 nm
Width = 3.3 m
Depth = 100 nm
Coarse
Fine
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PDMS
TESPSA-PDMS
RGDPDMS
Faculty: Peter I. Lelkes, PhD, Drexel University; R. J. Composto, P. Uttayarat, PhD, University of .Pennsylvania; and S. Chaturvedi,
Rohm and Haas.
E-mail: [email protected]
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School of Biomedical Engineering, Science & Health Systems
NANOTISSUE ENGINEERING RESEARCH
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Electrospinning of Conducting Nanofibrous Scaffolds
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Unique Features:
• Use of electroactive, nanofibrous scaffolds for tissue engineering purposes.
• Capability of generating oriented / aligned scaffolds.
• Electrospinning of pure PANi nanofibers / scaffolds.
• Co-electrospinning of natural ECM proteins (collagen) / biodegradable polymers.
• Generation of novel electroactive scaffolds by co-electrospinning of PLA with carbon
nanotubes.
Faculty: Peter I. Lelkes, PhD, F. Ko, PhD, Levy, Y. Wei, PhD, Drexel University; A. MacDiarmid, PhD, University of Pennsylvania.
E-mail: [email protected]
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School of Biomedical Engineering, Science & Health Systems
NANOTISSUE ENGINEERING RESEARCH
Tissue Engineering of Fetal Mouse Lung Using Collagenous
Scaffolds
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Porous foam (pore size equals ~ 10 nm).
Nanofibrous matt (fiber diameter < 100 nm).
Faculty: Peter I. Lelkes, PhD, Mondrinos, S. Koutzaki, PhD, V. Finck, PhD, F. Ko, PhD, Drexel University.
E-mail: [email protected]
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V 1.0 SD [040227]