Transcript Convenient

Microwave
Stimulators
NANS
December 6th, 2012
Laura Tyler Perryman, MS, MBA
PhD Candidate, Arizona State University
Disclosures
 Laura Tyler Perryman, MS, MBA, CSM, PMP
 Founder, Stimwave Technologies, Inc.
 Founder, Neural Diabetes Foundation, Inc.
 PhD Candidate, Biomedical Engineering, ASU
 Discussing NON-APPROVED devices for
neuromodulation indications
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Revolutionizing Pain Management
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Neural Stimulation Electrodes
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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FNS Neuroprostheses
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Neuromodulation Effectiveness
 Size- Is the lead small enough to go anywhere?
 Convenience- Is it possible to tunnel to the target?
 Complexity- Is a custom pulse generator required?
 Acuity- can effects be long term?
 Contact Positioning- can electrodes be positioned
to activate nerve bundles?
 Contact Geometry- can electrodes be designed to
optimize the field with safe charge density?
 Correlation- electrode location correct to provide
therapeutic relief?
 Pulse parameters- Pulse width, frequency,
waveform, bursts?
 Pulse Sequences- multichannel, variability, cross
talk?
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
Page 6
The Time is Right
Neuromodulation
market expected to
more than double
in size by 2018
-Neurovascular Guidewire
Market, 2012
Market size $1.8B
in 2011, projected
to grow to $4.7B by
20171
-Global
Data Report, 2011
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
Page 7
Clinician and Patient Needs
 Clinician (start with top down rather than bottom up)
 Less Procedure Time
 Flexibility
 Permanent with Minimal Incision
 Multiple Leads
 Built in Anchoring
 Existing Leads
 Patient
 Convenience
 Ease of Use
 Stay out of hospital overnights
 Easy upgrade pathways for existing patients
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Page 8
Old School Product Development
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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21st Century Product Development
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Disruptive MicroStimTM Solution
Passive microsize device platform for pain management
 No internal batteries or toxic materials
 3T full body MRI conditional goal*
 14-22 Ga needle insertion widens reach targets
1 cm to 6 cm long leads, 0.5 mm to 1.2 mm diameters
2 to 8 electrodes per lead depending on placement
Convenient external ergonomic stimulator wearable unit
 915 MHz ISM band (868 Mhz for EU)
 Penetration depths to 12 cm (SCS is ~4 cm to 6 cm)
 Currents up to 25.5 mA per MicroFlex device
*pilot data. Pending additional data
and submission
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for use by any
persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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No Battery, No Sticky Skin Charger
 Patient MUST carry programmer to
change amplitude and settings
 Rechargeable IPGs also require
the external coil system
 IPG primary cells replaced ~ every
3 years
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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NOT a BION® or Inductive
 Other wireless products utilizing coils need
coils externally
 Large external is difficult for the patient to
wear, limiting compliance
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Microwave SCS Components
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Same Efficacy, Tried and True
 Charged Balanced, biphasic pulses
 Selection of polarity of electrodes
 Pulse frequencies up to 1200 Hz (future to 5000 Hz)
 Pulse widths from 50 to 500μs (future to 1ms)
 Option for placement of dual arrays crossed
 BUT- Only one lead!! 8 electrode percutaneous version
How do you revolutionize an industry with a new
technology platform?
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Any Lead Flexibility
 No open port EVER
 100% percutaneous 14G placement
 No batteries, No extension tunneling
 No revisions every 4 to 7 years
 Use MicroFlexTM with ANY lead or paddle, 8
or 16 contact lead header
 Passive MicroStimTM forward compatible
 MRI expanded capabilities
Sample commercial
paddle leads
Sample commercial
percutaneous leads
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Convenience
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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MicroStimTM Advantages
 Size- 95% smaller than next smallest available
generator, fits within anchor or lead (250 mg)
 Passive device with simple architecture
 No internal battery, -easily upgradeable
 Electronic “complexity” outside of body
 Convenience- Elegant, percutaneous
procedure, takes 75% less time
 Safe- limits infection sources
 Flexible- turn key or easily adaptable header
to convert any lead or paddle to use
MicroStimTM with wide array of options
 Compliant- compact discreet external device
with Bluetooth utilizes breakthrough
engineering for energy and information
transmission
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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Thank You
Go Forward. Revolutionize.
Laura Tyler Perryman. Copyright 2012. All rights reserved. This document has been disclosed on a confidential basis and is not for
use by any persons but the named recipient, nor may it be reproduced, stored, or copied in any form.
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