Transcript Fragala - LIFE at UCF - University of Central Florida
University of Central Florida
Preventing Sarcopenia
Muscular Adaptations to Strength Training ExeRcise in Seniors
Maren Fragala, PhD, CSCS*D Institute of Exercise Physiology & Wellness
“Sarcopenia”
• Greek words sarx (flesh) and penia (loss) = the process of age-related loss of skeletal muscle mass and size Reason for creating term: •
“…no decline with age is as dramatic or potentially more significant than the decline in lean body mass.”
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“…if this phenomenon were to be taken seriously, we had to give it a name.”
Irwin H. Rosenberg, MD (1989)
2 Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997 May;127(5 Suppl):990S-991S.
Prevalence of Sarcopenia
asm/m 2 < 2 SD
New Mexico Elder Health Survey
(1993-1995)
Sarcopenia 14% No Sarcopenia 86% No Sarcopenia 50%
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14% in those aged 65–69 y Sarcopenia 50% >50% in those 80 y or older
Baumgartner et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am. J. Epidemiol. 1998. 147(8): 755–763.
Difficulty with daily tasks
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Physical disability was ~ 4X greater in sarcopenic older men and women than in older persons with a normal muscle mass No Sarcopenia 50% Sarcopenia 50%
Baumgartner et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am. J. Epidemiol. 1998. 147(8): 755–763.
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No diagnosis
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NO accepted clinical criteria for diagnosis
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NO pharmaceutical interventions to treat symptoms
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Our Objective: To determine if a novel blood biomarker relates to muscle adaptations Implications:
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Treatment of the debilitating condition
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The study…
Muscular Adaptations to Strength Training Exercise in Seniors (MASTERS)
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MASTERS Study Video
Skeletal Muscle
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Blood test
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Results: (Part 2) Blood Test
5,5 5,0 4,5 4,0 3,5 3,0 9 Exercise pre Control (baseline =4.53 + 1.80 to post = 4.88 + 1.86) post 2000 1500 1000 500 0 -500 0 -1000 -1500 -2000 -2500 5 10 15 (r = 0.422, p = 0.045)
Baseline P3NP (ng/mL)
Fragala MS, et al. Biomarkers of Muscle Quality: N-Terminal Propeptide of Type III Procollagen and C-terminal Agrin Fragment Responses to Resistance Exercise Training in Older Adults. Journal of Cachexia, Sarcopenia and Muscle. 2014 (In Press).
Special Thanks
The motivated and dedicated participants!
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Graduate Students!