Transcript phenotype sex

NORMAL SEXUAL
DIFFERENTIATION
Suganda Tanuwidjaja
IDENTITAS GENDER
1.
Genotype
2.
Gonadale Sex
3.
Phenotype Sex
4.
Social Gender
GENOTYPE
Chromosomal
(Genetic) Sex
Testis-Determining
Genes
XY
XX
Ovary-Determining
Genes
Gonadale Sex
Gonadale Steroids
And Peptidas
(T.DHT.AMH)
(Gonadale Steroids)
♂
♀
Phenotypic Sex
CHROMOSOMAL SEX
• Male
: 46 XY
• Female : 46 XX
Y Chromosome (SRY Gene)
Diff. of The Bipotential Gonad
Testis
X Chromosome
One Dose Active
GONADAL SEX
• Gonadal Sex is determined by SRY
• Indiff. Gonad (SRY)
(+SRY)
Ovary
Testis
1 X Chromosome : SRY
Gonad
Ovary (Fetal Periode)
Ova Atrophy
(Only 1 Chr)
STEROID METABOLISM OF GONAD
Androgen
Cholesterol
Enzim
Estrogen
PHENOTYPE SEX
• Internal Ducts
• External Genital Appearance
• Peran Androgen
INTERNAL SEX DUCTS BIPOTENTIAL
Masculine
Wolffian Ducts
Feminine
Mullerian Ducts
TESTICULAR PEPTIDE PRDCT
(SERTOLI CELL)
Mullerian Duct Inhibitory Factor (MIF)
Mullerian Duct Atrophy
Wolffian Duct Developed
WITHOUT...
MIF
Developed :
• Uterus
• Oviduct
• Upper 2/3 of Vagina
LEYDIG CELL
Testosteron
Wolffian Ducts
• Epididymis
• Vas Deferens
• Seminal Vesicle
EXTERNAL GENITALIA
• Bipotential
8 Weeks
• Genital Tubercle
Clitoris
• Urogenital Fold
Labia Minora
• Labioscrotal Swelling
Labia Majora
Testosterone
Dihydrotestosterone
(DHT)
5α Reductase Enzyme
Androgen Receptor (ARs)
Genital Tubercle
Penis
DHT
ARs
Urogenital Slit
Penile Urethra
Labioscrotal Fold
Scrotum
1st TRIMESTER
Maternal Human Chorionic Gonadotropin
(hCG)
Fetal Testes
Testosterone
Male Development
2nd TRIMESTER
Fetal Pituitary Gonadotropin
Testicular Activity
Further Normal Growth
of The Penis
SOCIAL GENDER
• Gender Development :
1. Gender Identity
2. Gender Role
3. Sexual Orientation
4. Desire & Capacity for Parenting
DETERMINED FACTORS
• Surrounding
• Physical Differentiation
• Interaction
• Prenatal Androgen
Thank You