Transcript superficial fungal infection dermatophytosis

SUPERFICIAL FUNGAL
INFECTION
DERMATOPHYTOSIS
THREE GENERA KNOWN TO CAUSE DISEASE
-TRICOPHYTON
- MICROSPORUM
- EPIDERMOPHYTON
EPIDEMIOLOGY
• GEOPHILIC -
– M.GYPSEUM
– M. FERRUGINEUM
- T. TERRESTRE
- T.VIOLACEUM
• ZOOPHILIC -
- M. CANIS – CAT, DOGS,SHEEPS
- T. EQUINUM – CATS, DOGS,CATTLES
- T. VERRUCOSUM – CATS , DOGS, CATTLES,SHEEPS
• ANTHROPOPHILIC -E. FLOCCOSUM
–M. AUDOUINII
–T. MENTAGROPHYTES
–T. RUBRUM
– T. TONSURANS –
PATHOGENESIS
• FUNGI MUST OVER COME
- EFFECT OF UV LIGHT
–TEMPERATURE VARIATION
– COMPITION WITH NORMAL FLORA
-FUNGISTATIC AGENTS –
• FATTY ACIDS,SPHINGOSINES
• - EPIDERMAL GROWTH
• DTH IMMUNE RESPONSE
TINEA CAPITIS
ECTOTHRIX
ENDOTHRIX
YELLOW- GREEN FLUORESCENCE
DULL GRAY-GREEN FLUORESCENCE
M.AUDOUINII
M.CANIS
M.FERRUGINEUM
T.SCHOENLEINII
NO FLUORESCENCE
NO FLUORESCENCE
M.GYPSEUM
T.MENTAGROPHYTES
T. RUBRUM
T.TONSRANS
T. VIOLACEUM
ORGANISMS ASSOCIATED WITH
CLINICAL TYPES OF TINEA CAPITIS
INFLAMMATORY NONINFLAMMATORY BLAK DOT
ZOOPHILIC
GEOPHILIC
ANTHROPOPHLIC
ECTOTHRIC
ANTHROPOPHILIC
ENDOTHRIX
M.AUDOUINII
M. CANIS
M. GYPSEUM
M.AUDOUINII
M. CANIS
M.FERRUGINEUM
T.TONSURAN
S
T.VIOLACEUM
T.MENTAGROPHYTE
T.TONSURANS
T. VERRUCOSUM
T.TONSURANS
FAVUS
M.GYPSEUM
T. SCHOENLEINII
T.VIOLACEUM
TINEA CAPITIS
TINEA CAPITIS
TINEA CAPITIS
BLACK DOT TINEA CAPITIS
INFLAMMATORY T. CAPITIS
TINEA BARBAE
• INFAMATORY TYPET. MENTAGROPHTE, T. VERRUCOSUM
• SUPERFICIAL TYPE ANTHROPOPHILIC –T. VIOLACEUM,T.RUBRUM
• CIRCINATE TYPE
TINEA BARBAE
TINEA FACEII
TINEA FACEII
TINEA BARBE
TYPICAL TINEA CORPORIS
TINEA CORPORIS
INFLAMMATORY T. CORPORIS
TINEA CORPORIS
TINEA CORPORIS
TINEA CORPORIS
TINEA CORPORIS
TINEA UNGUIUM
TINEA UNGUIUM
TINEA UNGUIUM
TINEA MANUM
TINEA MANUM
TINEA MANUM
TINEA CRURIS
TINEA CRURIS
TINEA CRURIS
TINEA CRURIS
TINEA CRURIS
TINEA PEDIS
•
•
•
•
CHRONIC INTERTRIGINOUS TYPE
CHRONIC HYPERKERATOTIC TYPE
VESICULOBULLOUS TYPE
ACUTE ULCERATIVE TYPE
TINEA PEDIS
TINEA PEDIS
TINEA PEDIS
TINEA PEDIS
TINEA PEDIS
KOH MOUNT
ENDOTHRIX FUNGUS
ECTOTHRIX FUNGUS
100X
TREATMENT
SYSTEMIC THERAPY
TOPICAL THREAPY **
SYSTEMIC ANTIFUNGALS
• ALLYLAMINS
•
•
•
•
–
INHIBITS SQUALENE EPOXIDASE BLOCKING BIOSYNTHESIS
OF ERGOSTEROL
FUNGICIDAL
3 TO 6 mg/kg OD
CONTRAINDICATED IN PREGNANCY & LACTATION
• TRIAZOLES
.
– ITRACONAZOLE, FLUCONAZOLE
INHIBIT 14 alfa DEMETHYLASE ENZYME IN CELL
MEMBRANE USEFUL FOR CONVERSION OF SQUALENE TO
ERGOSTEROL
IMIDAZOLE
– KETOCONAZOLE
GRISEOFULVIN
– DISRUPS MICROTUBULE MITOTIC
SPINDLE FORMATON THUS ARREST MITOTIC AT METAPHASE
STAGE
TREATMENT
TOPICAL
-ALLYLAMINES –
TERBINAFINE,NAFTIFINE
-BENZYLAMINE BUTENAFINE
-IMIDAZOLES
CLOTRIMAZOLE,
MICONAZOLE,
KETOCONAZOLE
-TOLNAFTAE
THANK YOU….,