Transcript Prostate Pathology

Prostate Pathology
Part 1
Francisco G. La Rosa, MD
Associate Professor, Department of Pathology
University of Colorado Denver, Aurora, Colorado
NORMAL ANATOMY
SAGITAL SECTION OF THE PROSTATE GLAND
Seminal
Vesicle
Central Zone
Bladder
Peri-urethral
zone
Transition
Zone
Peripheral
Zone
Anterior Zone
Fibro-muscular
Urethra
3D VIEW OF THE PROSTATE
3D VIEW OF THE PROSTATE
CROSS SECTION OF THE PROSTATE
FIBROMUSCULAR STROMA
anterior
PERI-URETHRAL
STROMA
EJACULATORY DUCTS
TRANZITIONAL
ZONE
Urethra
Seminal Vesicle
CENTRAL
ZONE
Peripheral Zone
Fibro-muscular Stroma
anterior
HISTOLOGY
Bad Histology
Peripheral Zone
Central Zone
Central Zone
Central Zone
Central Zone
Central Zone
40X
Seminal Vesicles
20X
Seminal Vesicles
20X
Seminal Vesicles
Paraganglion
40X
Neurons
Benign Lesions
Inflammation
Acute Inflammation
Acute Inflammation
Acute Inflammation
Acute Inflammation
Granuloma
20X
Corpora Amylacea
20X
Corpora Amylacea
Calcified
200X
Cristalloid
200X
Stromal Nodules
H Y P E R P L A S I A
PRIMARY NODULAR HYPERPLASIA
BENIGN NODULAR HYPERPLASIA
Usual Patterns
Cell Type
Special Patterns
Mesenchymal
Predominantly
stromal
Mixed
Fibroblast
Smooth Muscle
Leiomatous
Hyperplasia
Basal Cells
Basal Cell
Hyperplasia
Predominantly
glandular
Secretory Cells
Crybiform
Hyperplasia
Small Cell
Hyperplasia
BENIGN NODULAR HYPERPLASIA
BENIGN NODULAR HYPERPLASIA
BPH & Inflammation
BPH & Inflammation
BASAL CELL HYPERPLASIA
200X
BASAL CELL HYPERPLASIA
200X
BASAL CELL HYPERPLASIA
BASAL CELL HYPERPLASIA - HMWCK
ATROPHY
20X
SIMPLE ATROPHY
200X
ATROPHY
40X
ATROPHY
10X
CYSTIC ATROPHY
PIN
Prostatic Intraepithelial Neoplasia
Prostatic Intraepithelial Neoplasia
Mild
Secretory
cells
Carcinoma
Dysplasia
Lumen
Moderate
Severe In situ Microinvasive
Normal
Basal Cells
Basal
Membrane
Low Grade
High Grade
Prostatic Intra-epithelial Neoplasia
Prostatic Intra-epithelial Neoplasia
Prostatic Intra-epithelial Neoplasia
Prostatic Intra-epithelial Neoplasia
It continues in Part 2