Transcript Jacob van Klaveren

National Institute
for Public Health
and the Environment
ACROPOLIS
Jacob van Klaveren
Contents
• History and starting point
• Aims of ACROPOLIS
• Main overview (WPs)
• Project organisation
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for Public Health
and the Environment
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Starting point for ACROPOLIS
• An electronic platform for pan-European
exposure modelling as created in SAFE FOODs
• Existing models like EuroPOEM, CONSEXPO,
MCRA, IPRA
• EFSA opinions on cumulative risk assessment
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for Public Health
and the Environment
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Aims of ACROPOLIS
National Institute
for Public Health
and the Environment
•
Improve cumulative exposure and hazard assessment
•
Create new models for aggregated exposure assessment
•
Setting up new toxicological testing for identifying synergistic
effects
•
To integrate cumulative and aggregated risk models
•
Improve understanding of methodology of different stakeholders
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E-platform of databases (food and residue)
SE
NL
CZ
UK
IT
FR
0.4
0.2
0.0
-3.6
-2.9
-2.2
-1.4
-0.7
0.0
0.7
1.4
2.2
2.9
3.6
MCRA-software
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Toxicological BMD modeling
van der Voet & Slob (2007)
• Critical effect dose
• Number of experiments
• EFSA opinion BMD modeling
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Aggregated exposure assessment
Combine leading models in Europe
(MCRA, EUROPOEM, ConsEXPO)
Case studies with two or more different routes of
exposure
Validation of the model
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for Public Health
and the Environment
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Mixtures and internal does
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Model and software development
Internet compatible model and data
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for Public Health
and the Environment
•
Test and justify underlying assumptions
•
Scientific sound
•
Reproducible and transparent (reference manual MCRA openly
available)
•
Include quantitative uncertainty analyses
•
Data in connection with model available for stakeholders
(including industry). Not the raw data.
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Risk based on Margin of Exposure
Be aware that safety factors are also modelled!
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for Public Health
and the Environment
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Dissemination
•
Training
•
Stakeholder conferences
•
Website and folders
•
Scientific paper on stakeholders attitudes towards
cumulative and aggregated exposure levels
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for Public Health
and the Environment
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Stakeholders
• Industry
• Regulators
• EFSA and risk assessors at national level
• Risk Management
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for Public Health
and the Environment
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ACROPOLIS PROJECT STRUCTURE
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for Public Health
and the Environment
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External advisory board
EFSA (Luc Mohimont)
DG Sanco (Bas Drukker)
EPA (D. Miller will be asked)
Coordinator
- Further elaboration on case studies
- Overview needs of DG Sanco (risk managers)
- Fine-tune research needs of EFSA
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for Public Health
and the Environment
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Scientific Advisory Board
WHO, FAO, experts (dr. C. Harris, prof A. Boobis, prof
W. Steurbout, dr. D Hamilton), Greenpeace (dr. M.
Krauter), Industry (Bayer, BASF, Syngenta)
- To convey relevant issues from a stakeholders perspective
- To bring in relevant expertise (e.g. from USA)
- Emerging issues in pesticide risk assessment
- Implementation of project outcomes at EU level
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Deliverables and milestones
A deliverable is a result that has to be produced
(e.g. a paper, a model, or any other result)
A milestone is something that you have to achieve
before you can continue
All have to be done in time and as promised
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for Public Health
and the Environment
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Project Management Team
• A representative of each beneficiary
• Stop-go decisions
• Contingency plan (coordinator)
• Financial issues as far as they deviate from proposal
• Gender issues
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for Public Health
and the Environment
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National Institute
for Public Health
and the Environment
Thanks for your attention!
[email protected]
MCRA model
EFSA opinion
RIKILT report
: https://mcra.rikilt.wur.nl/
: EFSA website