Powerpoint - Johns Hopkins Medicine

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Transcript Powerpoint - Johns Hopkins Medicine

Making and Erasing Memories

Richard L. Huganir Department of Neuroscience Johns Hopkins University School of Medicine Howard Hughes Medical Institute

The Brain is a Network of 100 Billion Neurons

The Brain has Quadrillions of Synapses QuickTime™ and a Animation decompressor are needed to see this picture.

Synaptic Transmission QuickTime™ and a Animation decompressor are needed to see this picture.

Synaptic Plasticity at Synapses QuickTime™ and a Animation decompressor are needed to see this picture.

Synaptic Plasticity at Synapses QuickTime™ and a Animation decompressor are needed to see this picture.

Synaptic Plasticity at Synapses QuickTime™ and a Animation decompressor are needed to see this picture.

Synaptic Plasticity at Synapses QuickTime™ and a Animation decompressor are needed to see this picture.

Long-Term Potentiation QuickTime™ and a Animation decompressor are needed to see this picture.

Long-Term Depression QuickTime™ and a Animation decompressor are needed to see this picture.

Kibra Regulation of Receptor Function

Beautiful Synapses

Cranial Window

Imaging Receptors in Live Mice QuickTime™ and a decompressor are needed to see this picture.

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Sensory Stimulation Recruits Receptors to Synapses Control Stimulation 0 hour 1 hour 2 hour 3 hour

Spatial Learning - Water Maze Before Training After Training QuickTime™ and a Motion JPEG OpenDML decompressor are needed to see this picture.

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Fear Learning and Memory - Fear Conditioning QuickTime™ and a decompressor are needed to see this picture.

Fear Extinction: a Form of Behavioral Therapy Extinction Learning

Fear Extinction: a Form of Behavioral Therapy Extinction Learning Extinction Retrieval

Fear Extinction: a Form of Behavioral Therapy Extinction Learning Extinction Retrieval Relapse

Synaptic Plasticity During Fear Learning QuickTime™ and a Animation decompressor are needed to see this picture.

24 Hrs after Fear Learning QuickTime™ and a Animation decompressor are needed to see this picture.

7 Days after Fear Learning QuickTime™ and a Animation decompressor are needed to see this picture.

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Positive Allosteric Modulators of mGluR1 PAM Ro-0711401: 9H-xanthene-9-carboxylic acid (4-trifluoromethyl-oxazol-2-yl)-amide

Kibra Regulation of Receptor Function

Huganir Lab Yoichi Araki Shu-Ling Chiu Monica Coulter Kirsten Bombach Min Dai Graham Diering Huaqiang Fang Hana Goldschmidt Ahleah Gustina Lisa Hamm Seok Heo Ingie Hong Natasha Hussain Richard Johnson Olof Lagerlof Trisha Lala Brain Loeper Bian Liu Richard Roth Raja Sekhar Kamal Sharma Gek Ming Sia Mengnan Tian Alyssa Toda Lenora Volk Rebecca White Yong Zhang

Funding

HHMI NINDS NIMH Simons Foundation ADRC Pilot Grant