Transcript Hematopoietic - Pesticide Health Effects Medical Education

Effects of Pesticides Identified
in the Hematopoietic System
Pesticide Health Effects Medical Education Database (PHEMED)
Effects
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Hemolysis
Methemoglobinemia
Hypoprothrombinemia
Hyperkalemia
Hypocalcemia
Hypercalcemia
Carboxyhemoglobinemia
Anemia
• Leukopenia,
thrombocytopenia
• Elevated LDH, GOT,
GPT, alkaline
phosphatase, ALT, AST
enzymes
• Depressed RBC
acetylcholinesterase &
plasma
pseudocholinesterase
Hematopoietic
Effect
Characteristic of poisoning w/
• Hemolysis
• Naphthalene
• Sodium chlorate
• Arsine
• Hypoprothrombinemia • Coumarins
• Indandiones
• Methemoglobinemia
• Sodium chlorate
• Creosote
• Carboxyhemoglobinemia • Organotin compounds
Hematopoietic
Effect
Characteristic of poisoning w/
• Leukopenia
• Thrombocytopenia
• Inorganic arsenicals
• Anemia
• Naphthalene
• Sodium chlorate
• Arsine
• Inorganic arsenicals
Blood Chemistries
Effect
Characteristic of poisoning w/
• Hyperkalemia
• Hypocalcemia
• Sodium chlorate
• Naphthalene
• Arsine
• Fluoride
• Hypercalcemia
• Cholecalciferol
Enzymes
Effect
Characteristic of poisoning w/
Elevated LDH, GOT,
GPT, alkaline
phosphatase,
ALT, AST enzymes
• Carbon tetrachloride
• Chloroform
• Phosphine
• Depressed RBC
acetylcholinesterase
and plasma pseudocholinesterase
• Organosphosphates