Transcript The Patient with Heart Failure
The Patient with Heart Failure CPAP as an Intervention
April 2011 CE Condell Medical Center EMS System Site Code #107200E -1211 Prepared by: Lt. William Hoover, Medical Officer Wauconda Fire District Reviewed/revised by: Sharon Hopkins, RN, BSN, EMT-P 1
Objectives
Upon successful completion of this module, the EMS provider will be able to: Define heart failure and congestive heart failure.
Identify causes of heart failure.
Identify symptoms of heart failure.
Identify patterns of medical history related to the patient with heart failure.
Identify current home medications typically taken by the patient with congestive heat failure.
2
Objectives cont’d
Identify the difference between the patient with congestive heart failure and pneumonia.
Identify the assessment of the patient with congestive heart failure.
Identify the proper procedure for assessing breath sounds.
Identify treatment goals and options for congestive heart failure following Region X SOP’s.
Define CPAP as used by EMS for the patient with pulmonary edema.
3
Objectives cont’d
Describe how CPAP will benefit the patient with pulmonary edema.
State indications, contraindications and medications used with CPAP.
Describe the process of setting up the CPAP device.
Describe the process of adding in-line Albuterol with CPAP.
Describe patient assessment while delivery CPAP.
State components to document when using CPAP.
4
Objectives cont’d
Demonstrate the set up of CPAP.
Demonstrate the set-up of regular and in-line Albuterol.
Demonstrate adding in-line Albuterol with CPAP.
Actively participate in case scenario discussion.
Successfully complete the post quiz with a score of 80% or better.
5
What is Heart Failure?
A clinical syndrome Heart’s mechanical performance (ie: pumping action) is compromised Cardiac output unable to meet the demands of the body’s needs Generally divided into backward ventricular failure (right heart failure) and forward ventricular failure (left heart failure) Can be of a chronic or acute nature 6
Heart Failure
Variety of causes Valve disease Heart disease Contributing factors to heart failure Diet - excess fluid or salt intake Hypertension Pulmonary embolism Excessive alcohol or drug usage Progression of an underlying disease 7
What is CHF?
Congestive heart failure = CHF Condition of excess build-up of fluid in the lungs and/or other body parts/organs Fluid build-up causes congestion in the organs seen as edema May be brought on by diseased heart valves, hypertension, or some form of obstructive pulmonary disease Often a complication of AMI 8
Fluid build-up in CHF may be pulmonary, peripheral, sacral, or ascites 9
Understanding CHF
A failure of the pumping action of the heart Heart is a 2 sided pump Right side of heart is a low pressure system Left side of heart is a high pressure system 10
Heart as a Pump
Left side of heart muscular Needs to overcome pressure in the arteries to push/pump blood Pumps blood flow to the body Right side of heart less muscular Pumps blood to the lungs • Does not need to be a very aggressive pump with a lot of force 11
Starling’s Law
The more the myocardial muscle is stretched, the greater the force of contraction (the greater the recoil) Greater the preload (amount of blood returned to the right heart), the farther the myocardium is stretched and the more forceful a contraction that results leading to an increased cardiac output When Starling’s Law fails, the patient is no longer able to compensate 12
Hypertension
B/P is a measurement of force against the wall of the arteries When vessels stiffen due to calcium build up (arteriosclerosis) and plaque develops (atherosclerosis), vessels are less compliant Higher pressures are needed to pump blood through stiffer vessels 13
Right Ventricular Failure
Failure of right ventricle as a forward pump Back pressure of blood into systemic venous circulation system Common causes Left ventricular failure (AMI) Systemic hypertension Pulmonary hypertension Cor pulmonale – heart disease due to pulmonary disease (ie; effects of COPD) 14
Progression of Right Heart Failure
Right ventricle cannot eject all of the blood out Fluid/pressure builds up • In right atrium Backs up into the venous system Results in pedal/dependent edema Visible as JVD 15
Right Sided Heart Failure A Systemic Picture
16
Left Ventricular Failure
Failure of left ventricle to function as a forward pump Back pressure of blood into pulmonary circulation Often causes pulmonary edema Common causes Various types of heart disease • • Ischemia / acute MI Coronary artery disease (CAD) arteriosclerosis/atherosclerosis • • • Valve disease Chronic hypertension Dysrhythmias afterload 17
Progression of Left Ventricular Failure
Left ventricle cannot eject all the blood delivered from the right heart via the lungs Left atrial pressure rises and transmitted to pulmonary veins and capillaries These high pressures force blood plasma into alveoli (ie: pulmonary edema) Oxygen capacity of lungs reduced Hypoxia develops Acidosis develops 18
Pulmonary Edema
Severest form of congestive heart failure Left ventricular forward failure Think
l
eft/
l
ungs Patient develops respiratory distress due to fluid in the lungs Note: extremely rare to have unilateral pulmonary edema; then related to unusual pathology/med hx 19
Pathophysiological Changes in Pulmonary Edema
Left ventricle cannot empty effectively Fluid moves from capillary beds into surrounding interstitial tissue alveoli Fluid in alveoli impedes oxygen exchange Surfactant lining alveoli washes out Alveoli stiffen Alveoli collapse after each breath and are harder to open Lungs develop compliance, airflow obstruction, hyperinflation to workload of breathing 20
Symptoms of CHF
In the more chronic setting of
right heart failure
, symptoms usually related to excess fluids in organs and other body parts In the more acute
left heart failure
, symptoms usually related to excess fluid in the lungs and therefore respiratory distress 21
Signs and Symptoms Right Heart Failure
Dependent edema Peripheral edema Hepatomegaly Splenomegaly Jugular vein distension (JVD) Ascites Weight gain Dysrhythmias Nausea/vomiting Fatigue Dizziness Syncopal episodes Weakness 22
Signs and Symptoms Left Heart Failure
Shortness of breath Dyspnea Orthopnea Crackles Wheezing Hypoxia Respiratory acidosis Chest pain Sweating Productive cough Blood tinged sputum Cyanosis Palpitations Dysrhythmias Hypertension Anxiety/restlessness 23
Typical medical history pattern of patient with CHF Hypertension Cardiovascular disease (CVD) Myocardial infarction (MI) Coronary artery disease (CAD) Arteriosclerosis Atherosclerosis Smoker Excessive alcohol or drug use Cocaine Methamphetamine Inhaled solvents PCP Dietary intake excess fluids, excess salt High cholesterol 24
Typical home medication history pattern of patient with CHF Diuretic Digoxin contractility force of the heart (inotropic) Home oxygen therapy Anti-hypertensive ACE inhibitors (end in “pril”) Beta blockers • • heart rate & force of contractions B/P Often end in “olol” Calcium channel inhibitors • • Slows movement of calcium into small muscles wrapped around blood vessels relaxing blood vessels peripheral vascular resistance relaxing blood vessels 25
Herbal remedies that may be harmful when mixed with heart failure St. John’s wort Ephedra Gingko biloba Kava Licorice Ginseng Aconite Alisma plantago Bearberry buchu Couch grass Dandelion Horsetail rush Juniper 26
Evaluation CHF/PE History
HTN, heart problems
Dyspnea Recent hx Cough Onset
Orthopnea, PND Acute weight gain, dependent edema Frothy sputum Rapid
B/P Meds Tx
High Dig, anti-HTN, diuretic O 2 , NTG, lasix, MS
Pneumonia
n/a Orthopnea possible Fever, malaise Productive thick green Gradual Normal Antibiotic, cold prep O 2 , neb, fluids
COPD
Lung problems Chronic; pursed lips Gradual weight loss Chronic; productive Gradual Normal Bronchodilators , steroids O 2 , neb 27
Symptom SOB Cough Sputum Fever Skin Chest pain Smoking hx Wheezing Crackles
Separating Signs/Symptoms
CHF/PE
Yes
Pneumonia
Yes
COPD
Yes Maybe Frothy pink No Yes Early a.m.
Yellow/green Thick brown Yes Cold/clammy Hot/dry No Normal or dusky Possible Maybe No Possible Maybe; bilateral Possible Maybe; same side as disease Yes; bilateral Maybe; same side as disease Usually Usually, bilateral No 28
A Note…
“Old geezers don’t become new wheezers!”
COPD develops over a long period of time. If an elderly person does not have a history of COPD and they are suddenly wheezing, think a cardiac problem or pulmonary edema.
Assume the worst, hope for the best
29
Patient Assessment - CHF
Acute findings Recent trouble sleeping • trips to the bathroom at night • Orthopnea with number of pillows • Sleeping in the recliner • New episodes of paroxysmal nocturnal dyspnea (PND) • use of nitroglycerin to stop chest pain • use of oxygen 30
Patient Assessment - CHF
General impression Labored respirations Audible noisy respirations Tripod positioning Frothy sputum production work of breathing – retractions, tachypnea Wheezing/crackles bilaterally Diaphoretic Change in skin color from norm Severe anxiety/restlessness Severe hypertension may be present 31
Patient Assessment - CHF
Signs and symptoms pulmonary edema Tachypnea Orthopnea PND Noisy labored respirations Fine crackles/rales Wheezing – “cardiac asthma” Coarse crackles/rhonchi larger airways Coughing with frothy blood tinged sputum 32
Obtaining Breath Sounds
Use flat diaphragm surface of stethoscope Rub stethoscope head between hands to warm it up before placing on patient’s skin If audible sounds are heard, ask patient to cough gently to clear upper airway Auscultate side to side and top to bottom Anterior: Posterior: 33
Adventitious (Extra) Breath Sounds
Check for asymmetry Crackles: high pitched, continuous sounds like rubbing hair between fingers Wheezes: generally high pitched, of musical quality Stridor: Harsh inspiratory wheeze indicating upper airway obstruction Rhonchi: snoring or gurgling quality Any extra sound not a crackle or wheeze is usually rhonchi 34
Decision Making –What to Do?
Use critical thinking skills Decide if patient is sick or not Obtain current and past history Obtain vital signs Look Skin (wet/dry; color; temp) JVD present or not Peripheral / dependent edema present Subtle signs Listen Breath sounds 35
Making the Right Decision
Does the medical history include cardiovascular disease?
Does the physical examination/patient assessment paint a picture of CHF?
Use critical thinking skills Not treating pulmonary edema means the body becomes more hypoxic and acidotic Miss diagnosis (ie: pneumonia) could prove lethal This patient will arrest 36
Treatment Goals for CHF
Decrease myocardial workload Decrease oxygen demand Decrease fluid retention Correct hypoxia Correct acidosis 37
Treating CHF/Pulmonary Edema
Decrease myocardial workload No physical activity (they don’t walk to the rig) Sitting the patient upright; dangle feet Administering oxygen – non-rebreather CPAP to increase oxygen absorption surface of lungs Medications to Nitroglycerin preload and afterload Morphine Lasix – additionally works as diuretic 38
Treatment Goals for Pneumonia
Supply supplemental oxygen as needed Treat the bacterial infection Hydrate the patient • • • Usually found in the elderly Often vague symptoms; use to feeling ill Immune system often already weakened so mortality rate is high with this diagnosis 39
Region X SOP- Acute Pulmonary Edema
Begin Routine Medical Care Take standard precautions Perform assessments Identify priority patient and make transport decisions • • Stay and play?
Load N go?
Perform routine tasks • IV-O 2 -monitor 40
What About the IV and Nitroglycerin?
Region X Medical Directors discussion: Majority of patients in pulmonary edema will be hypertensive Nitroglycerin will help reduce preload which will lower blood pressure (beneficial) Do not delay NTG dose, if no contraindications, to start the IV • If patient deteriorates before IV established, can always place an IO 41
Region X SOP- Acute Pulmonary Edema
Determine if the patient is
stable unstable
or Stability guided by status of perfusion B/P and level of consciousness If stable, the patient can receive more aggressive care including medications and procedures (ie: CPAP) If unstable, Medical Control needs to coordinate degree of care provided in the field (ie: meds and CPAP) 42
Region X SOP- Acute Pulmonary Edema - Stable
Nitroglycerin
Nitrate vasodilator Decreases myocardial workload • • • Dilates arterial and venous systems preload afterload Carefully monitor blood pressure Screen for concomitant use of sexual enhancement drug • • Viagra or Levitra in last 24 hours Cialis in past 48 hours 43
Stable Pulmonary Edema SOP
Lasix
Loop diuretic Moves sodium (NA + ) out of blood vessels • Water follows sodium • Potassium (K + ) also pulled out Vasodilation effects within 5 minutes • Decreases preload Diuresis within 20-30 minutes Peaks within 30 minutes 44
Stable Pulmonary Edema SOP
Morphine sulfate
Narcotic analgesic • Reduces anxiety Dilates venous and arterial systems • preload • afterload • blood pressure Stimulates nausea center in the brain Slows respiratory rate in medulla 45
Region X SOP – Pulmonary Edema Medication Regimen
Stable patient Nitroglycerin 0.4 mg sl • One every 3-5 minutes to max dose of 3 Begin CPAP Lasix 40 mg IVP (80 mg if taken at home) Morphine 2 mg IVP slow over 2 minutes • May repeat 2 mg every 2 minutes to max of 10mg If wheezing, contact Medical Control for possible Albuterol neb treatment 46
CPAP
C
ontinuous
p
ositive
a
irway
p
ressure Delivered throughout the respiratory cycle Noninvasive ventilatory support
Most beneficial when initiated early
Maintains airway in open position intrathoracic pressure which return to the heart venous Preload and afterload both decrease 47
Benefits of CPAP
Increases amount of inspired oxygen Decreases work load of breathing Reduces need for intubation Intubation requires ICCU stay • Increased exposure to risks associated with complications due to intubation • Increases overall hospital length of stay 48
Redistribution of extravascular lung water during use of CPAP
Without CPAP With CPAP 49
50
Indications for CPAP
Patient in acute pulmonary edema with stable blood pressure Stable B/P = >100mmHg systolic FYI – with revised 2011 SOP’s, blood pressure levels will be shifting to systolic of 90 as a consistent guideline throughout the SOP’s 51
Contraindications for CPAP
Decreased or altered level of consciousness Inability of patient to protect their airway from aspiration Persistent nausea/vomiting Need for immediate intubation Hemodynamic instability (B/P<100) Note: B/P guideline will be changing to <90 with revised 2011 SOP Penetrating chest trauma 52
Medications Simultaneous With CPAP
Medications should be started NTG sl Then begin CPAP Then continue medication administration as indicated Lasix – 40mg or 80mg IVP Morphine – 2 mg IVP repeated every 2 min
CPAP will buy time for the medications to work
53
Did you know… It is not
either / or
(CPAP or meds) CPAP works
WITH
medications in tandem
Lift the mask to continue administration of more NTG 54
CPAP Equipment
Fixed whisper flow Connects to your oxygen source 55
O
2
Tank Duration
Approximate time at 30% FIO 2 D tank E tank M tank H tank 30 min.
50 min.
253 min.
508 min.
*based on 50 psi output 56
CPAP Circuit Set-up
Package includes: Mask Tubing Head strap CPAP valve Air entrainment filter CPAP valve Filter 57
Most patients need a lot of coaching to initially tolerate the tight fitting mask 58
If The Patient is Wheezing
Contact Medical Control to consider an order for Albuterol via nebulizer Medical Control needs to give this physician’s order Contact ECRN on radio • Needs to give the ED MD a report • • Obtains MD’s order Relays the response to EMS If Albuterol is given, monitor for cardiac side effects (ie: tachycardia) 59
In-line Albuterol Set-up with CPAP
Cut the CPAP corrugated tubing as close to patient as possible in smooth area of tubing Splice Albuterol kit T piece in-line Remove the mouthpiece and place the adaptor (used for in-line Albuterol) Connect adaptor to distal cut end of corrugated CPAP tubing Remove Albuterol corrugated tubing and connect proximal end of CPAP tubing to T piece of Albuterol Keep Albuterol cup upright Albuterol kit still needs to be hooked to O 2 60
CPAP With In-line Albuterol Set-up
61
Criteria to Discontinue CPAP
Development of hemodynamic instability B/P drops below 100 systolic • Revised 2011 SOP B/P level will be 90 systolic Inability of patient to tolerate tight fitting mask Emergent need to intubate the patient 62
Patient Monitoring During Use of CPAP
Constant reassessment required: Patient tolerance Mental status Respiratory pattern Rate, depth, subjective feeling of improvement Blood pressure, pulse, SaO 2 , EKG rhythm Complications Gastric distension, nausea, vomiting 63
Monitoring Improvement With CPAP
It’s working when: Level of distress decreases Respiratory rate is returning toward normal Pulse oximetry (SaO 2 ) increasing Pulse rate decreasing toward normal Decrease in use of accessory muscles Ability to speak in fuller sentences returning 64
Contacting Medical Control
Remember: Early communication with receiving hospital Hospital needs to get their regulator for oxygen source connection • Usually not kept in each room 65
Documentation With CPAP
Assessment leading your general impression to a diagnosis of pulmonary edema CPAP level provided (10cmH 2 O) FiO 2 provided (100%) SaO 2 serial levels Vital signs over time Response to treatment Any adverse reactions noted 66
So, What’s Different About BiPAP?
Bi
-level
p
ositive
a
irway
p
ressure Uses 2 levels of pressure Helps move more air into lungs without need to exhale against higher pressures CPAP is a larger & noisier machine Uses extra effort to exhale and can be tiring Both can be used for sleep apnea BiPAP easier on those with COPD and neuromuscular diseases 67
Case Scenarios Small Group and Large Group Discussions
Read the presentation Form a general impression Discuss treatment options Discuss what/how/when to reassess the patient Decide what treatment to continue or what adjustments need to be made Note: Additional questions are asked on ppt that can be discussed during group presentations.
68
Case Scenario #1
Dispatch:
You are called to a 70 y/o man c/o breathing problems
HPI:
Increasing shortness of breath for 1 day despite the use of inhalers
PmHx:
COPD, Hypertension, and Diabetes
Medications:
Albuterol Inhaler, Lasix, and Aspirin
Allergies:
Penicillin 69
Case Scenario #1
Physical Exam:
Thin white man on home oxygen breathing through pursed lips sitting in a tripod position
Vital Signs:
B/P 180/90; HR 120 sinus tachycardia; RR 30; SaO airway patent 2 88%; LOC alert;
Head & neck:
Perioral cyanosis, no JVD
Pulmonary:
Lung auscultation reveals inspiratory and expiratory wheezes
Extremities:
Cyanotic, no pedal edema 70
Case Scenario #1
What is your general impression?
Are assessment findings stronger for exacerbation of COPD or for acute pulmonary edema?
COPD supported History Appearance Lung sounds What treatment is indicated?
71
Case Scenario #1
IV – O 2 , monitor
Albuterol nebulizer started:
• 5 min Vital Signs: B/P 160/90; HR 130; RR 24; SaO 2 92%, LOC Alert; lung sounds unchanged • 10 min Vital Signs: B/P 120/90; HR 120, RR, 24, SaO 2 92%, LOC Alert; lung sounds less prominent wheezing; subjectively patient breathing easier 72
Case Scenario #2
Dispatch:
65 y/o woman c/o of shortness of breath
HPI:
1 week history of progressive dyspnea with exertion. Unable to lay down flat without shortness of breath, no chest pain or cough
PmHx:
Hypertension, Diabetes
Medications:
Lasix, Atenolol, and Glucaphage 73
Case Scenario #2
Physical Exam:
260 lb woman sitting in recliner.
Vital Signs:
B/P 160/80; HR 140 sinus tachycardia; RR 30; SaO 2 78%, LOC follows commands; airway patent
Head & neck:
Cyanosis, JVD present
Pulmonary:
Crackles in all lung fields
Extremities:
Cyanotic, 3+ pedal edema 74
Case Scenario #2
What is your general impression?
Are assessment findings stronger for exacerbation of COPD or for acute pulmonary edema?
Pulmonary edema supported History Appearance Lung sounds What treatment is indicated?
75
Case Scenario #2
Need to move rapidly Minimize scene time as much as possible IV-O 2 -monitor Start nonrebreather until switched to CPAP Consider AMI so obtain 12 lead EKG Any contraindications to treatment?
Nitroglycerin?
NO CPAP?
Lasix?
Morphine?
NO NO NO 76
Case Scenario #2
After CPAP started:
5 min Vital Signs: B/P 100/60; HR 100; RR 24; SaO 2 stimuli 84%; LOC: responds to verbal 10 min Vital Signs: B/P 60/40; HR 30; RR 6; SaO 2 60%; LOC unresponsive 77
Case Scenario #2
What is your general impression now?
Patient is deteriorating What is your treatment now?
CPAP needs to be discontinued Patient needs to be bagged and intubated • • One breath every 5-6 seconds before intubation One breath every 6-8 seconds after intubation Hold further repeats of medications used Consider need for dopamine infusion 78
Case Scenario #3 Documentation
Initial impression was acute pulmonary edema Based on physical assessment; history; recent hospitalization for CHF Treatment was routine medical care IV – O 2 non-rebreather- monitor CPAP started after ordered by Medical Control 2 sets of vital signs documented Initial vital signs (B/P 170/98 – 92 – 32) Second reading at the hospital 79
Case Scenario #3 Comments Documented
Upon arrival patient found sitting upright, agitated, complaining of chest pain and difficulty breathing. Audible congested breathing standing next to patient. Unable to complete a full sentence. Bilateral pedal edema noted. Began oxygen via nonrebreather. IV started. Moved patient to ambulance. Medical Control contacted and ordered CPAP to be started. Patient becoming more agitated. After 5 minutes, SaO becoming easier.
2 increasing. Patient stated breathing was 80
Case Scenario #3 Documentation cont’d
Patient transported sitting upright. Continued CPAP during entire call. Transported patient into ED on portable O 2 with CPAP continued.
81
Case Scenario #3 Documentation cont’d
Pt contact: 0954 Depart scene: 1025 “Drugs” 0959 - Oxygen - 15 l – non-rebreather 1001 – 0.9 NS 1000ml – TKO – IV 1005 – CPAP /oxygen – 15l – CPAP mask “`Cardiac rhythm” 0958 – sinus 1035 - sinus 82
Case Scenario #3 Documentation Discussion
What went well?
Recognized pulmonary edema CPAP used with positive patient response 83
Case Scenario #3 Documentation Discussion
What could be improved upon?
Long on-scene time (0954 – 1025 -31 mins) Delay in initiating O 2 therapy – 5 minutes Waited for MC to order CPAP – 11 min delay • No Medical Control direction needed to initiate No other meds given for pulmonary edema Only 2 sets of vital signs taken on a critical patient 84
Case Scenario #4
Dispatch:
You are called to a 84 year-old female c/o breathing problems
HPI:
Running low grade fevers, not feeling well for 4 days
PmHx:
MI, Hypertension, TIA’s
Medications:
Plavix, Lasix, Lisinopril
Allergies:
Iodine, shellfish 85
Case Scenario #4
Physical Exam:
Vital Signs:
B/P 142/80; HR 96 sinus rhythm; RR 28; SaO 2 92%, LOC follows commands; airway patent
Head & neck:
Pale, no JVD
Pulmonary:
Crackles in right lower lung field
Extremities:
Pale, pedal pulses palpable 86
Case Scenario #4
What is your general impression?
Are assessment findings stronger for acute pulmonary edema or pneumonia?
Pneumonia supported?
History Appearance Lung sounds not so helpful What treatment is indicated?
87
Case Scenario #4
What is your treatment now?
IV-O2-monitor Fluids • Faster than keep open but not a fluid challenge Diagnosis confirmed at the hospital with chest x-ray and labs 88
Case Scenario #4
Patients with pneumonia need fluids Patients with congestive heart failure need fluid restrictions A wrong diagnosis and therefore wrong treatment approach could be harmful for both patients 89
Case Scenario #5
Dispatch:
You are called to a home for a 78 year-old male with severe SOB
HPI:
Has been getting progressively SOB past 2 days; slept in recliner last night
PmHx:
MI x3; hypertension, diverticulitis, seizures
Medications:
Aspirin, Hydrodiuril, Verapamil, NTG PRN, Coumadin, Phenobarbital
Allergies:
none 90
Case Scenario #5
Physical Exam:
Vital Signs:
B/P 172/96; HR 110 sinus tachycardia; RR 36; SaO 2 88%, LOC follows commands; extremely anxious; airway patent
Head & neck:
JVD
Pulmonary:
Crackles mid way up lung fields bilaterally
Extremities:
Cyanotic, pedal edema palpable 91
Case Scenario #5
What is your general impression?
What is your treatment plan?
Write a run report Include initial assessment Document treatment interventions indicated Document reassessment performed Discuss as a group what needs to be included 92
93
94
Bibliography
Bledsoe, B., Porter, R., Cherry, R. Paramedic Care: Principles and Practices. Brady. 2009.
Limmer, D., O’Keefe, M. Emergency Care, 10 th Edition. Brady. 2005.
Region X SOP’s March 2007; Amended January 1, 2008.
http://whisperflow.respironics.com/ www.emsworld.com
Variety internet websites for CPAP and pulmonary edema 95