Transcript Rb & Control of the Cell Cycle

Figure 8.1 The Biology of Cancer (© Garland Science 2007)
Figure 8.3b The Biology of Cancer (© Garland Science 2007)
Kinetics of Cyclin D1 after mitogenic
stimulus
Figure 8.8 The Biology of Cancer (© Garland Science 2007)
Many Growth Factor-Stimulated Pathways Upregulate Cyclin D
Waxing & Waning of Cyclin-CDK Complexes
Figure 8.12 The Biology of Cancer (© Garland Science 2007)
Families of Cyclin-CDK Inhibitors
Figure 8.14a The Biology of Cancer (© Garland Science 2007)
Figure 8.15a The Biology of Cancer (© Garland Science 2007)
Recall the AKT/PKB – mTOR Axis
Figure 16.44a The Biology of Cancer (© Garland Science 2007)
AKT Directs Growth-Sparing Compartmentation
of p27Kip1 (and p21Cip1 too)
Figure 8.16b The Biology of Cancer (© Garland Science 2007)
Paradoxical Effects of p21 and p27 on Cyclin DCDK4/6 VS other Cyclin-CDKs
Figure 8.17a The Biology of Cancer (© Garland Science 2007)
Rb’s Actions are Regulated by its State of Phosphorylation
Phosphorylation Determines Rb-E2F Interaction
Figure 8.22 The Biology of Cancer (© Garland Science 2007)
+ Feedback loop
Cyc E-CDK2 Promotes Destruction of p27
Cyclin E
transcription
Figure 8.25b The Biology of Cancer (© Garland Science 2007)
The Rb Family of Pocket Proteins
p105 (Rb); p107 & p130
Figure 8.21a The Biology of Cancer (© Garland Science 2007)
E2F/DP and Transcription
(Associated with
Hypophosphosphorylated Rb family
members)
(Free E2F-DP complexes)
During G1Cooperation Among Pathways
(mostly) Favors D1 Accumulation
Figure 8.26 The Biology of Cancer (© Garland Science 2007)
Myc, Max & Mad-Max
Figure 8.27 The Biology of Cancer (© Garland Science 2007)
Myc & Its Collaborators Promote D/CDK & Decrease
Rb Inhibition of R Point Transit
Figure 8.28 The Biology of Cancer (© Garland Science 2007)
TGFβ can Trump Myc
Figure 8.31 The Biology of Cancer (© Garland Science 2007)
Myc can Influence Differentiation
Figure 8.34 The Biology of Cancer (© Garland Science 2007)
A Web of Interactions & Pathways Influence
R Point Transition
Figure 8.35 The Biology of Cancer (© Garland Science 2007)