Transcript Janeway`s Immunology

Immune effector function
Induction of adaptive immunity
Differentiation of Th
Cytokines
Cell-mediated immunity
Humoral immunity
Immunological memory
Foreign Ags……….
對外
Gene rearranged
receptors: TCR/BCR
Adaptive immunity
Four characteristics
1. Antigen specificity
2. Diversity
3. Immunological memory
4. Self tolerance
Clonal selection
Antigen
specificity
Diversity
Central tolerance
Immune diversity
Memory
Peripheral tolerance
Sites of
effector function
Primary (Central):
Bone marrow 骨髓
Thymus 胸腺
Secondary (Pheripheral):
Lymph nodes 淋巴結
Spleen 脾臟
Peyer’s patches
Lymph node
distribution
in the body
Immunity & Ag location
Humoral response
Ag
Extracellular
Intracellular
(Altered self)
Innate
Adaptive
2 B cells
Phagocytes
CD4 Th
NK
1 CD8 Tc cells
Cytotoxicity
Cell-mediated immunity (CMI)
Induction of
adaptive immunity
Phagocytes
Inflammation
Dendritic cells (DC)
Antigen-Presenting Cells (APC)
Lymph node
B/T cells
Inflammatory
site
Lymphocyte activation
Clonal selection
Humoral Imm/CMI
Memory
Inflammatory site
T cell
activation
DC
HEV
Lymph node
T
Immune effector function
Induction of adaptive immunity
Differentiation of CD4 Th
Cytokines
Cell-mediated immunity
Humoral immunity
Immunological memory
Effector
Activation
Naïve, activated, effector
Cell-mediated immunity (CMI)
Humoral immunity
Priming
The activation and
differentiation of
naïve T cells
Three signals
in naïve T cell
activation
Costimulation
Professional APC
Signal 1
Ag & MHC presentation pathways
Foreign
or
Self Ag
DC/Macrophages/B cells
Signal 2
Signal 2 alone
Signal 1+2
CD4 T cell
activation
IL2R
IL2 production
Clonal expansion
Professional APC
Lack of signal 2
upon T cell
activation
Peripheral tolerance
Negative
regulation
of signal 2
upon
T cell activation
Inhibition of
activated T cells
Peripheral tolerance
CD4 T cell
differentiation
Th17
Promote
local
inflammation
CMI: CD8 T
Humoral response
Signal 3: cytokine
Immune effector function
Induction of adaptive immunity
Differentiation of Th
Cytokines
Effector
response
Cell-mediated immunity
Humoral immunity
Immunological memory
Activation
Innate
immunity
Effector
phase
Rapid T cell response to infection: Th17
Amplifier of acute
Inflammation
(local site, BM)
IL17
Ubiquitous expression of IL17R:
fibroblasts, epithelial cells, keratinocytes, etc.
IL6
Chemokines
G-CSF
GM-CSF
Recruitment of neutrophils
Expression of antimicrobial peptides
Activation of macrophages
CD4 T cell
differentiation
CMI
CD8 T
Humoral
immunity
CMI: Macrophages
activated by Th1
APC activation
CMI:
CD8T
cytotoxic
response
Cytotoxic granules
Membrane
effector
molecule
Effector T cells
Immune effector function
Induction of adaptive immunity
Differentiation of Th
Cytokines
Effector
response
Cell-mediated immunity
Humoral immunity
Immunological memory
B cells as APC
Effector Th2 cells
Humoral immunity:
B cell response
CD4T-dependent:
1. Isotype switching
2. Somatic hypermutation
Affinity maturation
3. Memory
Effector response
CD4 Th17, Th1/ Th2
CD8 Tc
B cells
Immune effector function
Induction of adaptive immunity
Differentiation of Th
Cytokines
Cell-mediated immunity
Humoral immunity
Immunological memory
Adaptive
immunity
Protective immunity & time
Memory cells:long-lived
Apoptosis of effectors