Embase

Find quick, relevant answers to your biomedical questions

Section 1.

Review / Confirm understanding of your research needs

Section 1.

Your challenges & Research Needs

• Conduct systematic reviews of the literature • Set up complex search strategies and alerts for stakeholders and departments • Search Medline and Embase together • Set up and distribute alerts relating to evidence-based medicine • Access the most up to date information related to a disease that you are tracking • Make sure that all relevant information is disseminated throughout the organization • Monitor and track all adverse events for early and complete detection of any and all adverse effects (signaling) • Make sure you respond to your internal stakeholder’s request in a timely manner

Section 2.

Evidence Based Medicine / Systematic Searching

Section 2. “

How do you know if one treatment will work better than another, or if it will do more harm than good?

” Cochrane Reviews are systematic reviews of primary research in human health care and health policy, and are internationally recognized as the highest standard in evidence-based health care . They investigate the effects of interventions for prevention, treatment and rehabilitation. They also assess the accuracy of a diagnostic test for a given condition in a specific patient group and setting. They are published online in

The Cochrane Library

.

Section 2. “

How do you know if one treatment will work better than another, or if it will do more harm than good?

” Each systematic review addresses a clearly formulated question. For example:

Can antibiotics help in alleviating the symptoms of a sore throat?

All the existing primary research on a topic that meets certain criteria is searched for and collated, and then assessed using stringent guidelines, to establish whether or not there is conclusive evidence about a specific treatment. The reviews are updated regularly, ensuring that treatment decisions can be based on the most up-to-date and reliable evidence.

Section 2.

Case Study: Embase & Evidence Based Medicine

A real example of the high risks of NOT using Embase

Section 2.

Medicine Without Evidence

Johns Hopkins’ Tragedy:

Could Librarians Have Prevented a Death?

Source: http://newsbreaks.infotoday.com/nbreader.asp?ArticleID=17534

Section 2.

Section 2.

Section 2.

EBM Terms in Embase / Emtree

via Advanced Limits in Advanced Search via Emtree

Section 3.

What is Embase and How it Supports Academic Institutions

Section 3.

What is Embase?

Embase is the world ’ s most comprehensive, intelligent biomedical research tool, providing the drug and drug-related research community with reliable and authoritative content, to advance new biomedical and pharmaceutical discovery.

Confidence

Find all relevant articles that may not otherwise be found by alternative databases

Deep Biomedical Indexing

All relevant, up-to-date, biomedical information from the research literature

Precise Retrieval

Deep and focused research through powerful retrieval tools

Section 3.

How Embase Delivers Value…

...by including literature and information resources in a timely manner ...by reading full-text to identify

drugs, diseases, adverse affects,

clinical trials, drug trade names etc. ...

by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set Conference proceedings Scientific Journals In Press (unpublished)

Deep indexing using own taxonomy (EMTREE) Very powerful Search Environment

...by allowing users to automate searching and result management

We make sure you don’t miss any biomedical literature They only close alternative is reading all the articles Good precision and recall balance Automation and documentation

Section 3.1

Content

Section 3.1

Content Overview

Emtree:

Biomedical thesaurus, over 60k terms

Embase:

Fully indexed: Over 7,700 journals (including MEDLINE), 1950-

MEDLINE:

2,500 journals unique to Embase, mapped to Embase indexing, 1950- (including MEDLINE Classic)

Embase Classic:

Digitally scanned and re-indexed, 1947-1973

AIP and In Process:

Indexing added, from 2009

Conference Abstracts:

Indexing added, from 2009 2009 1947 1950 And counting … 2,700 records added per day 1,000,000 records added per year 1974

Section 3.1

Embase Scope & Coverage (2012)

Pharmacology & Taxicology 12% General Clinical Medicine 11% Genetics, Biochemistry & Molecular Biology 10% Neurology & Behavioral Medicine 8% Microbiology & Infectious Disease 7% Cardiology & Hematology 6% Psychiatry & Mental Health 6% Oncology 5% Healthcare Policy & Management 4% Allergy & Immunology 4% Pediatrics 4% Endocrinology & Metabolism 3% Obstetrics & Gynecology 3% Biomedical Engineering & Medical Devices 3% Anesthesiology & Intensive Care 3% Gastroenterology 2% Respiratory Medicine 2% Nephrology & Urology 2% Dermatology 2%

Other topics 28%

Including public health, basic biomedical science and topics included from MEDLINE

Section 3.1

Embase vs MEDLINE – Scope

Similar overall pattern of coverage

... but with two major differences

1. Pharmacology & toxicology

Embase: 11.2% (889 titles) MEDLINE: 8.3% (465 titles)

2. General clinical medicine

Embase: 10.5% (835 titles) MEDLINE: 8.9% (495 titles)

Section 3.1

Embase vs MEDLINE – Searching the Difference

Section 3.1

Embase Records

Section 3.1

1.0 m 800 K 600 K 400 K 200 K

Embase Records Medline on PubMed

01 02 03 04 05 06 07 08 09 10 11

Section 3.1

Embase (Active) Journals in 2012

Embase:

now covers 7960 journals (20 March 2012) Indexed at Embase (5396 titles) Indexed by MEDLINE (e.g on PubMed) (5592 titles)

2368 journals

Indexed at Embase Unique to Embase

Search:

[embase]/lim

3028 journals

Indexed at Embase Also covered by MEDLINE

Search:

[embase]/lim AND [medline]/lim

2564 journals

Indexed by MEDLINE Also in MEDLINE

Search:

[medline]/lim NOT [embase]/lim

Section 3.1

1.0 m 800 K 600 K 400 K 200 K

Journal Articles Conference Abstracts

01 02 03 04 05 06 07 08 09 10 11

Section 3.2

Indexing (Emtree Thesaurus)

Section 3.2

Deep Indexing – EMTREE

Emtree is a Life Science Thesaurus. A controlled vocabulary for Biomedicine and related Life Sciences 

Easy to Search

Over 60,000 preferred terms and more than 270,000 synonyms 

Comprehensive Drug Searching

Chemical names, trade names, laboratory/research codes, and more than 28,000 generic drugs and chemicals (FDA, EMEA and WHO) 

Up-To-Date

The latest drugs, diseases, organisms and procedures are indexed and added annually 

Inclusive Terminology

All MeSH terms, with links to more than 20,000 CAS registry number

Section 3.2

Deep Indexing – EMTREE

60K terms (>260,000 synonyms) and all MeSH terms 29K drug and chemical terms Emtree updated 3 times a year (back-posting each time) All drug generic names described by FDA and EMA, all International Non-Proprietary Names (INNs) described by WHO from 2000.

What is mapping?

Mapping means that searchers get the same results regardless of which term they use, e.g. Vioxx (synonym) or rofecoxib (the preferred term).

Section 3.2

Deep Indexing – EMTREE

Database Thesaurus

Embase Emtree

Search

'monoclonal antibody'/exp/dd_dt AND 'breast cancer'/exp/dm_dt AND [2009-2010]/py

[Note: dt = drug therapy]

PubMed MeSH "Antibodies,Monoclonal /therapeutic use“[Mesh] AND "Breast Neoplasms/drug therapy"[Mesh] Limits: Publication Date from 2009 to 2010 Embase vs. PubMed : in-depth indexing + Emtree tree structure

Result

2075 357

Section 3.2

Embase vs PubMed

2 thesaurus assisted searches but different results!

Section 3.2

Embase vs PubMed

This article, although present in Medline, is not indexed with ‘digoxin’ and therefore our search for ‘digoxin’ and ‘antibacterial agents’ did not find this article – it’s found in Embase.

Section 3.2

Embase vs MEDLINE – Randomized Controlled Trails

Language

Turkish Korean Portuguese Dutch Chinese Polish Spanish French German

Embase on Elsevier

613 134 712 606 5366 491 2316 3952 8393

Medline on Ovid

75 46 442 442 3945 434 2137 3904 8566

Embase Advantage 538 88 270 164 1421 57 179 48 -173 Percent 717% 191% 61% 37% 36% 13% 8% 1% -2%

Section 3.2

Embase vs MEDLINE – Searching for Drugs

Product Name 2

Liptor Advair Plavix Nexium Norvasc Enbrel Zyprexa Remicade Diovan Risperdal

Search Term Emtree Preferred Term

Atrovastatin Fluticasone propionate plus Salmeterol Clopidogrel Esomeprazole Amlodipine besylate Etanercept Olanzapine Infliximab Valsartan Risperidone

MeSH Preferred Term or Substance Name 3

Atrovastatin 3 Fluticasone propionate plus Salmeterol 3 Clopidogrel 3 Omeprazole 4 Amlodipine 4 TNFR-Fc fusion protein 4 Olanzapine 3 Infliximab 3 Valsartan 3 Risperidone

Citations Embase

7,668 839

Medline

1,654 39 9,552 1,493 439 5,197 7,775 8,223 2,725 7,991 1,613 1,558 621 1,375 1,498 2,461 508 1,488