Transcript Biology of Cancer - Dr. Jennifer Staiger
Chapter 5/6:
GF,Receptors and Cancer/ Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer
Copyright © Garland Science 2007
Cell Signals and Control of Cell Behavior
Figure 5.1
The Biology of Cancer
(© Garland Science 2007)
Ras-Map Kinase Pathway From L. J. Kleinsmith,
Principles of Cancer Biology
. Copyright (c) 2006 Pearson Benjamin Cummings.
Tyrosine Kinase Behavior From L. J. Kleinsmith,
Principles of Cancer Biology
. Copyright (c) 2006 Pearson Benjamin Cummings.
Jak-STAT Signaling Pathway From L. J. Kleinsmith,
Principles of Cancer Biology
. Copyright (c) 2006 Pearson Benjamin Cummings.
Regulation Ras Activity From L. J. Kleinsmith,
Principles of Cancer Biology
. Copyright (c) 2006 Pearson Benjamin Cummings.
Intracellular Protien Kinases • Ras triggers a series of intracellular phosphorylation reaction.
• Serine/threonine kinases – BRAF and human melanoma • Intracellular Non-receptor tyrosine kinase – Src kinase – Jak kinase – Abl kinase
Other Oncogenes • Transcription Factors – Myc – Fos – erb • Genes involved in driving cell proliferation – Cyclin dependent kinases – Cyclins • Genes involved in inhibiting cell death – BCL-2 – MDM-2
Cell to Cell Communication Figure 5.2
The Biology of Cancer
(© Garland Science 2007)
Src: Protein Tryosine Kinase Figure 5.5a
The Biology of Cancer
(© Garland Science 2007)
Actions of Protein Kinases Figure 5.7a
The Biology of Cancer
(© Garland Science 2007)
EGF Receptor is a Tyrosine Kinase Figure 5.9a
The Biology of Cancer
(© Garland Science 2007)
EGF Receptor and v-ErbB Figure 5.11
The Biology of Cancer
(© Garland Science 2007)
Deregulation of EGF Receptor Figure 5.12a
The Biology of Cancer
(© Garland Science 2007)
GFs/Receptors and Cancer Table 5.2
The Biology of Cancer
(© Garland Science 2007)
Receptor Activation Figure 5.15
The Biology of Cancer
(© Garland Science 2007)
Non-Receptor Tyrosine Kinase Activation Figure 5.20
The Biology of Cancer
(© Garland Science 2007)
Ras Transformation and GF Signaling Figure 5.32a
The Biology of Cancer
(© Garland Science 2007)
Cytoplasmic Signaling Cascade
Signaling Begins at the Cell Surface
De novo Synthesis Unnecessary for Immediate Early Gene Expression
Signaling Begins at the Cell Surface
Serum Induced Changes in Cell Shape
Src Protein Domain Structure
Structure and Function of SH2 Domains
Interaction of Phosphorylated Receptors and Signal Transducers
Protein Binding Domains
Formation of Multiprotein Complexes
SH3 Domains and Ras Activation
Kinase Cascades Mediated by Ras
Ras Effector Loops
Ras Activation of PI3K
Activation of PI3K by Ras
Docking of PH Domains to PIP 3
PI3K/AKT Pathway and Cell Proliferation/Survival
Alterations in PI3K Pathway in Human Tumors
Other Pathways Involved in Cell Proliferation • Jak-STAT Pathway • Integrin Signaling Pathways • Wnt-b-Catenin Pathway • G-coupled Protein Receptors • NfkB Pathway • Notch Pathway • TGF-B Pathway
Jak-STAT Pathway
G-Coupled Protein Receptors
G-coupled proteins and Cancer
Cell Signaling Impacts a Variety of Cellular Processes