Transcript Fc[RI
FcɛRI Signalling Pathway The Ligand : IgE Mast and Basophil Cells • Fc receptors bind tail region of IgE antibodies. The Receptor Tyrosine Kinases Lyn Syk The Pathway Binding of IgE •Aggregation of receptors • Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor. Syk can also phosphorylate syk associated with adjacent receptor Syk activation Cascade of reactions Degranulation Allergy sufferers are at a lower risk of developing cancer Inverse association between IgE and malignancies • IgE-mediated immune responses against tumor cells • IgE-based treatment options • Click to edit the outline text format Second Outline Level Third Outline Level Fourth Outline Level Fifth Outline Level Sixth Outline Level Seventh Outline Level Eighth Outline Level Ninth Outline Level Click to edit the outline text format Second Outline Level Third Outline Level Fourth Outline Level Fifth Outline Level Sixth Outline Level Seventh Outline Level Eighth Outline Level Ninth Outline Level Click to edit the outline text format Second Outline Level Third Outline Level Fourth Outline Level Fifth Outline Level Sixth Outline Level Seventh Outline Level Eighth Outline Level Ninth Outline Level Click to edit the outline text format Second Outline Level Third Outline Level Fourth Outline Level Fifth Outline Level Sixth Outline Level Seventh Outline Level Eighth Outline Level Ninth Outline Level Click to edit the outline text format Second Outline Level Third Outline Level Fourth Outline Level Fifth Outline Level Sixth Outline Level Seventh Outline Level Eighth Outline Level Ninth Outline Level Click to edit the outline text format Second Outline Level Third Outline Level Fourth Outline Level Fifth Outline Level Sixth Outline Level Seventh Outline Level Eighth Outline Level Ninth Outline Level Click to edit the outline text format Second Outline Level Third Outline Level Fourth Outline Level Histogram not generating all first passage times Fifth Outline Level Sixth Outline Level Seventh Outline Level Eighth Outline Level Ninth Outline Level But it wasn't so bad Click to edit the outline text format Bngl easy to understand Second Outline Level Easy to define chemical Third Outline Level reactions Fourth Outline Level Can manipulate molecule concentrations Can set time period of Fifth Outline Level Sixth Outline Level Seventh Outline reaction Level Eighth Outline Level Ninth Outline Level