Transcript Microglia phenotypes in aging-associated diseases Yin, Zhuoran

Microglia phenotypes in aging-associated diseases
Yin, Zhuoran
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to
cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2017
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Yin, Z. (2017). Microglia phenotypes in aging-associated diseases [Groningen]: University of Groningen
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the
author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately
and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the
number of authors shown on this cover page is limited to 10 maximum.
Download date: 24-04-2017
Microglia phenotypes in agingassociated diseases
Zhuoran Yin
The research presented in this thesis was financially supported by The research presented in this thesis was financially supported by The research presented inChina Scholarship Council this thesis was financially supported by
China Scholarship Council China Scholarship Council
Deltaplan Dementie Deltaplan Dementie
Deltaplan Dementie Microglia phenotypes
in aging-associated diseases
Jan Kornelis de Cock Stichting
Jan Kornelis de Cock Stichting Jan Kornelis de Cock Stichting University Medical Center Groningen
University Medical Center Groningen University Medical Center Groningen Research Foundation-Flanders
Research Foundation‐Flanders Research Foundation‐Flanders Proefschrift
The printing of this thesisThe printing of this thesis was financially supported by was financially supported by
The printing of this thesis was financially supported by University of Groningen
University of Groningen University of Groningen University Medical Center Groningen
University Medical Center Groningen Research School of Behavioral and Cognitive Neurosciences
University Medical Center Groningen Research School of Behavioral and Cognitive Neurosciences Research School of Behavioral and Cognitive Neurosciences Paranymphs
Paranymphs: Clarissa Haas
Marissa Dubbelaar
Clarissa Haas Marissa Dubbelaar ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
Paranymphs: Clarissa Haas De openbare verdediging zal plaatsvinden op
maandag 13 maart 2017 om 14.30 uur
Marissa Dubbelaar Cover design: Zhuoran Yin, Hilmar van Weering, and Yang Heng
and surrounding zen circle are metaphors for the phenotypical change
On the cover: The microglia
of microglia.
Cover design: Zhuoran Yin Cover design: Zhuoran Yin door
On the cover: The microglia and surrounding zen circle are metaphors for the phenotypical change of Layout and printing: Off page,
Amsterdam
On the cover: The microglia and surrounding zen circle are metaphors for the phenotypical change of microglia. microglia. ISBN printed version: 978-94-6182-773-9
Layout and printing: Off page, Amsterdam Layout and printing: Off page, Amsterdam ISBN electronic version: 978-94-6182-775-3
Copyright © 2017 by Zhuoran
Yin. All rights reserved. All rights reserved. No part of this thesis may
ISBN printed version: 978‐94‐6182‐773‐9 ISBN printed version: 978‐94‐6182‐773‐9 be reproduced or transmitted in any form or by any means without prior permission of the author and
the publishers holding theISBN electronic version: 978‐94‐6182‐775‐3 copyrights of the published articles.
ISBN electronic version: 978‐94‐6182‐775‐3 Copyright © 2017 by Zhuoran Yin. All rights reserved. All rights reserved. No part of this thesis may Copyright © 2017 by Zhuoran Yin. All rights reserved. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without prior permission of the author be reproduced or transmitted in any form or by any means without prior permission of the author Zhuoran Yin
geboren op 22 januari 1987
te Anhui, China
Promotor
Prof. dr. H.W.G.M. Boddeke
TABLE OF CONTENTS
Chapter 1
General introduction and outline of the thesis
Copromotor
Dr. B.J.L. Eggen
Chapter 2
Immune hyperreactivity of Aβ plaque-associated microglia in
Alzheimer’s disease
37
Beoordelingscommissie
Prof. dr. P.P. De Deyn
Prof. dr. S.E.J.A. de Rooij
Prof. dr. T.A. Bayer
Chapter 3
Increased white matter inflammation in
aging- and Alzheimer’s disease brain
69
Chapter 4
Reversal of inflammation in the aging brain by
low-fat diet combined with calorie restriction
105
Chapter 5
Progressive motor deficit is mediated by the denervation of
neuromuscular junctions and axonal degeneration in
transgenic mice expressing mutant (P301S) tau protein
131
Chapter 6
Summary and general discussion
161
Chapter 7
Nederlandse samenvatting / Dutch Summary
175
7
Acknowledgement181
Curriculum vitae
191