Transcript Clinical and spinal radiographic outcome in axial spondyloarthritis

Clinical and spinal radiographic outcome in axial spondyloarthritis
Maas, Fiona
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2017
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Maas, F. (2017). Clinical and spinal radiographic outcome in axial spondyloarthritis: Results from the GLAS
cohort [Groningen]: Rijksuniversiteit Groningen
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Download date: 24-04-2017
Clinical and spinal radiographic outcome
in axial spondyloarthritis
Results from the GLAS cohort
Fiona Maas
ISBN: 978-90-367-9645-3
ISBN: 978-90-367-9644-6 (e-book)
Cover design
Agnes Schuur
Layout
Legatron Electronic Publishing, Rotterdam, The Netherlands
Printed by Ipskamp Printing, Enschede, The Netherlands.
© Fiona Maas, Groningen, 2017.
All rights reserved. No part of this publication may be reproduced or transmitted in any form
or by any means, without permission of the author.
The GLAS cohort was financially supported by unrestricted grants from Pfizer BV, Abbvie BV,
and UCB Pharma BV.
The printing of this thesis was financially supported by the Graduate School of Medical
Sciences of the University Medical Center Groningen, University of Groningen, Pfizer BV,
Celgene BV, UCB Pharma BV, and Abbvie BV.
Clinical and spinal radiographic outcome
in axial spondyloarthritis
Results from the GLAS cohort
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 8 maart 2017 om 14.30 uur
door
Fiona Maas
geboren op 24 september 1988
te Ten Boer
Promotor
Prof. dr. H. Bootsma
Copromotores
Dr. A. Spoorenberg
Dr. S. Arends
Beoordelingscommissie
Prof. dr. D.M.F.M. van der Heijde
Prof. dr. W.F. Lems
Prof. dr. M. Boers
CONTENT
Chapter 1
General introduction
PART I
Radiographic outcome of excessive bone formation in AS patients
treated with TNF-α inhibitors
Chapter 2
Spinal radiographic progression in patients with ankylosing spondylitis
11
27
treated with TNF-α blocking therapy: a prospective longitudinal
observational cohort study
Chapter 3
Reduction in spinal radiographic progression in ankylosing spondylitis
47
patients receiving prolonged treatment with TNF-α inhibitors
Chapter 4 Ankylosing spondylitis patients at risk of poor radiographic outcome
73
show diminishing spinal radiographic progression during long-term
treatment with TNF-α inhibitors
Chapter 5
Radiographic damage and progression of the cervical spine in
93
ankylosing spondylitis patients treated with TNF-α inhibitors:
facet joints vs. vertebral bodies
Chapter 6
Incorporating the cervical facet joints in the mSASSS is of additional
115
value in the evaluation of radiographic outcome in ankylosing spondylitis
Part II
Radiographic outcome of excessive bone loss in AS patients
Chapter 7
Radiographic vertebral fractures develop in patients with ankylosing
137
spondylitis during 4 years of TNF-α blocking therapy
Chapter 8
Clinical risk factors for the presence and development of vertebral
fractures in patients with ankylosing spondylitis
157
Part III
Influence of gender and BMI on disease outcome and the
development of a physical activity questionnaire for axial SpA
Chapter 9 Male and female patients with axial spondyloarthritis experience
181
disease activity, physical function, and quality of life differently:
results from the GLAS cohort
Chapter 10 Obesity is common in axial spondyloarthritis and associated with
189
poor clinical outcome
Chapter 11
Disease-specific questionnaire to assess physical activity in patients
203
with axial spondyloarthritis: the axSpA-SQUASH
Chapter 12
Summary and General Discussion
251
Chapter 13
Nederlandse Samenvatting
277
Dankwoord287
Curriculum Vitae 291
List of Publications
293