Transcript Flyer Webinar 20_02_2017

lunedì 20 febbraio 2017
ore 14:00, aula 2025, edificio U3
Deciphering cancer:
Genomic instability in cancer
Johnathan R. Whetstine, Ph.D. Massachusetts General Hospital Cancer Center Harvard
Medical School Charlestown, MA
Mark J. O’Connor, Ph.D AstraZeneca Cambridge, UK
While it is well established that DNA damage can increase the risk of cancer, changes to the
epigenome or the chromatin architecture are equally
important. DNA damage triggers a redistribution of DNA-binding proteins around the site of
damage, resulting in localized and temporary alteration of
chromatin structure. However, repeated cycles of DNA damage and repair may lead to permanent
changes in the epigenome, thereby promoting the
onset of diseases such as cancer. This webinar will examine how we may be able to develop
effective new therapeutic options for cancer treatment by
targeting proteins responsible for chromatin modifications.
During the webinar, the speakers will:
Highlight the mechanisms of tumorigenesis and genomic instability resulting from copy number
gains
Explain the different forms of DNA damage that lead to genomic instability and tumorigenesis
Investigate how understanding genomic instability can inform the development of cancer
treatments
Durata del Webinar: 61 min
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I BtBs-Webinar sono seminari online aperti a tutti, non hanno bisogno di essere prenotati e non bisogna portare il
proprio computer.
coordinatore: Reinaldo Alvarez, [email protected], tel. 3340