Transcript Quantitative CT myocardial perfusion Pelgrim, Gert

Quantitative CT myocardial perfusion
Pelgrim, Gert
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Publication date:
2017
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Pelgrim, G. (2017). Quantitative CT myocardial perfusion: Development of a new imaging biomarker
[Groningen]: Rijksuniversiteit Groningen
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Download date: 24-04-2017
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Quantitative CT myocardial perfusion
Development of a new imaging biomarker
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The Langendorff perfusion model is a feasible ex vivo validation tool for testing the
performance of several perfusion imaging techniques in controlled circumstances. (this
thesis)
In an ex vivo model, MBF quantification per segment detects differences in artificially
hypoperfused segments, with an FFR stenosis threshold < 0.80. (this thesis)
CT MBF measurements are highly dependent on the temporal sampling rate in
dynamic CT perfusion. (this thesis)
Dual energy iodine quantification scans should be performed using imaging protocols
with largest tube voltage separation to acquire most accurate iodine concentration
measurements. (this thesis)
Scan triggering in single shot CT acquisition should not extend the 8 second window for
discrimination between normal and ischemic myocardium. (this thesis)
The radiation absorption coefficient provides an optimal intravascular parameter for
the development of an imaging biomarker for myocardial perfusion. (this thesis)
Standardization in methodology, acquisition protocol and post-processing is
mandatory in the biomarker development of CT myocardial perfusion imaging. (this
thesis)
Integration of functional and morphological information from cardiac CT scans will
improve the diagnostic accuracy for detection of coronary artery disease. (this thesis)
Electieve diagnostische invasieve coronair angiografieën zouden gezien de
diagnostische performance van non-invasieve imaging technieken niet meer moeten
worden uitgevoerd.
Elke radiologie afdeling dient in de toekomst een technisch geneeskundige in dienst te
hebben.
Radiologen dienen de toekomst van hun werkveld te heroverwegen door de opkomst
van artificiële intelligentie.
Een PhD is als het op fietsen van een berg in de Franse Alpen, in het begin denk je dit
gaat goed en gemakkelijk, halverwege begin je te twijfelen over de haalbaarheid, vlak
voor het einde denk je dit ga ik nooit redden, en als je het uiteindelijk haalt kun
terugkijken op een hele mooie reis.
I like pigs. Dogs look up to us. Cats look down on us. Pigs treat us as equals. (Winston
Churchill)
Gert Jan Pelgrim, 2017