Transcript KU Alzheimer*s Disease Center* The Executive Director*s Perspective

KU Alzheimer’s Disease Center—
The Executive Director’s Perspective
Anne Arthur, BSN, MS, APRN-BC
KU Alzheimer’s Disease Center Executive Director
www.kualzheimer.org
Objectives
• Discuss the history of the KU Alzheimer’s
Disease Center (KU ADC)
• Identify the accomplishments of the KU ADC
since inception
• Explore ways the KU ADC can support
investigators
History of the ADC
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NIA-Division of Neuroscience
Established in 1984
Goal: promote research network on AD
29 centers in the US
National meetings twice a year
Alzheimer’s Disease Centers (ADC)—29
Timeline
1985
1990
1995
2000
2005
2010
2015
KU ADC
• Director: Russell Swerdlow
• 7 Cores
• Aims
1-Support AD, AD-related, and brain aging research
projects
2-Provide advanced services that facilitate groundbreaking metabolism research
KU ADC Structure
Administrative
Core
Clinical Core
Data
Management and
Statistics Core
Neuropathology
Core
Education and
Information
Transfer Core
Neuroimaging
Core
Mitochondria
Genomics and
Metabolism Core
KU ADC-Specific Cores
Administrative Core
Leader: Russell Swerdlow, MD
• Goals
– Provides oversight to the KU ADC
– Promotes AD, MCI and brain aging research
• Pilot Program
• Resource Request
– Expands KUs base of clinical, translational and
basic science investigators
• Collaborative REsearch Workgroup (CREW) meetings
Advisory Boards
Internal Advisory Board
Randy Nudo
Carol Cleek
Joseph Donnelly
Paul Terranova
Peter Smith
Richard Barohn
Steven Warren
Susan Kemper
Robert Krumlauf
External Advisory Board
Charles DeCarli
Angela Jefferson
Nigel Cairns
Walter Kukull
Thomas Montine
William Jagust
Teresa Radebaugh
Projects Supported
• 18 Federal
– 2 P01 (Michaelis, Kouhlen)
– 7 R01 (Burns, Williams, Berman, Zhu)
• 15 Foundation
• 5 Training awards
• 11 Therapeutic trials
– ADCS
– Alzheimer’s Drug Discovery Foundation
– Pharmaceutical
Clinical Core
Leader: Jeffrey Burns, MD
• Goals
– Cohort of nondemented, MCI and AD subjects
– Support and encourage collaborative
interdisciplinary studies
• Data
• Biological specimens
• Clinical research infrastructure
– Burns elected to National ADC Steering
Committee and ADC Clinical Task Force
Clinical Core
• 400 well-characterized participants
Normal
MCI
AD
> 60 y.o.
Any age
Any age
Enrolled to
date
119
51
58
234
Goal
200
100
100
400
Age
Total
Clinical Core Evaluation
Visit 1
Clinical
Evaluation
(CDR)
Yearly
Visit 2
Memory
Testing
Yearly
Visit 3
Labs/
Physical
Function
Testing/
DEXA
Every 3 years
Data Collection
• Clinical Evaluation
– Clinical Dementia Rating (CDR) Scale
– Neurological Exam
• Memory testing
Boston Naming Test
Block Design
Stroop
Free and Cued SRT
Letter Number Sequencing
• Physical Function testing
• DEXA scan
MMSE
Logical Memory I & II
Digit Span Forwards/Backwards
Category Fluency
Trailmaking A & B
Digit Symbol
Specimen Collection
• Processed and stored in the Biospecimen
Shared Resource (BSR) Center
Plasma
Buffy Coat
Platelets
Serum
Whole Blood
Cell-free Plasma
Cybrid Cell Lines
DNA
RNA
National Alzheimer’s Coordinating Center
(NACC)
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Established by NIA in 1999
Support all ADCs
Database for clinical and neuropath data
Partners
– National Alzheimer’s Disease Cell Repository
(NCRAD)
– Alzheimer’s Disease Genetics Consortium (ADGC)
• Free to investigators
Data/Specimen Sharing
KU ADC
National
Alzheimer’s
Coordinating
Center (NACC)
National Cell
Repository for
Alzheimer’s Disease
(NCRAD)/Alzheimer’s
Disease Genetics
Consortium (ADGC)
Data Management and Statistics Core
Leader: Jonathan Mahnken, PhD
• Goals
– Provide statistical expertise
– Develop Data and Information Management and
Monitoring Systems
• Mahnken elected to NACC Scientific Review
Committee 2011-2014
• Present national ADC meeting 10/2012
Neuropathology Core
Leader: Kathy Newell, MD
• Goals
– Autopsy human brain tissue from Clinical Core
participants
– Autopsy animal models
– Neuropathological consultation and specimen
sharing
Scanning and Imaging
Aperio Digital Scanning System
Nikon Eclipse 80i + Metamorph
Brain Autopsy Program
• Clinical Core participants
• Demented/non-demented brains
• Neuropathology Case Conference
– 2nd Thursday odd months, 4-5p, 1605 Surgical
Pathology, Microscope Room 2
Education & Information Transfer Core
Leader: Heather Anderson, MD
• Goals
– Recruit/retain subjects
• KU ADC Clinical Core cohort
• Clinical Trial Unit (CTU)
– Train students and health professionals
– Increase awareness of AD and the KU ADC
Recruitment/Retention
• Presentations
• Newsletters
• Social Media
– Facebook
– Twitter
– Electronic newsletter
• Birthday Cards
• Annual Appreciation Breakfast
Recruitment Sources
GrayHawk
Other
Public
Brochure
Health Care Professional
KU ADC Website
Newspaper Ad
Friend
Family
TV
Radio
Recruitment Flow
Ed Core
Clinical Trial
Unit
Clinical Core
InvestigatorInitiated studies
Education/Outreach
• Seminar Series on Health, Aging and Dementia
– Partner with LCOA and GPGEC
• Alzheimer’s and Aging Research Colloquium
– Partner with LCOA and GPGEC
• Healthy Aging Symposium
– Partner with JCCC
• Annual Appreciation Breakfast
• Lectures/presentations
• Student observership
Neuroimaging Core
Leader: William Brooks, PhD
• Goals
– Advanced scientific support and subsidized scans
for AD research
– Advanced training and education in imaging
– Develop novel imaging techniques for studies in
AD
Hoglund Brain Imaging Center
• Instrumentation
– 3 Tesla Siemens Skyra human MRI scanner
– 9.4T Varian/Agilent animal MRI scanner
– PET/CT Scanner (General Electric DST) (including cyclotron
CTI (Siemens RDS 111)
– 151-channel whole-head CTF MEG unit (including
simultaneous 160 channel EEG)
Novel Imaging Techniques
• Translation of imaging protocols to new 3T
scanner
• Glutathione (GSH) spectroscopic imaging
sequence
• Vitamin C spectroscopic imaging sequence
under development
• Neurochemical profile from MRS
Mitochondrial Genomics
& Metabolism Core
Leaders: Eli Michaelis, MD, PhD & Mary L. Michaelis, PhD
• Goals
– Prepare mitochondria, protein extracts, DNA, and
RNA
– Prepare cybrid cell lines
– Perform mtDNA sequencing and 8-OH-2-dG
measurements
– Assist in AD mitochondrial research
Support for Investigators
• Pilot Grant Program
• Resource Requests
• Collaborative REsearch Workgroup (CREW)
Meetings
Pilot Grant Program
• 3-4 grants awarded annually (July 1st)
– Dr. Nudo, Landon COA, funded 1 project yr 1 & 2
• $30,000 awarded/grant
• RFA 2nd week in December
• New and established investigators eligible to
apply
• Contact: Eric Vidoni, PhD
Resource Requests
• Investigators conducting research on aging,
MCI and AD can apply
– Consultation
– Services
– Research materials
• http://www.kualzheimers.org/alzheimersdisease-center/researcherresources/researcher-resource-request.html
Biospecimen Resources
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Brain Tissue
Buffy Coat
Cell-free Plasma
Cybrid Cell Lines
DNA
RNA
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Muscle
Plasma
Platelets
Serum
Whole Blood
Database Access
• Alzheimer’s Disease Neuroimaging Initiative
• National Alzheimer’s Coordinating Center
• Kansas University Brain Aging Project
Metabolism & Mitochondria Resources
• Physical fitness, glucose tolerance, metabolic rate, and
body composition testing
• Structural brain neuroimaging of humans and animals
• Metabolic neuroimaging of humans and animals (FDG
PET, AV-45 and MRS)
• Biochemical assays
• Mitochondria, protein extracts, DNA, and RNA
• Cybrid cell lines
• mtDNA sequencing and 8-OH-2-dG measurements
CREW Meetings
• Collaborative REsearch Workgroup (CREW)
meetings
• 3rd Monday of every month in Clinical
Research Center
• All investigators in aging and dementia
welcome to attend
How you can help
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Refer study participants
Collaborate with us
Spread the word
Cite us
Complete REDCap survey for any KU ADCaffiliated publications, presentations, etc.
https://redcap.kumc.edu/surveys/?s=Tpmj5i
KU ADC Team
Administrative Core
Russell Swerdlow, MD
Jeffrey Burns, MD
Anne Arthur, APRN
Eric Vidoni, PhD
Brad Amstein, BS
Clinical Core
Jeffrey Burns, MD
Anne Arthur, APRN
Russell Swerdlow, MD
Heather Anderson, MD
David Johnson, PhD
Phyllis Switzer
Hilary Dubinsky, BS
Diane Cunningham
Ashley Thompson
Education and Information Transfer Core
Heather Anderson, MD
Angela Van Sciver
Mitochondrial, Genomics and Metabolism Core
Eli Michaelis, MD, PhD
Mary Lou Michaelis, PhD
Russell Swerdlow, MD
Xinkun Wang, PhD
Data Management and Statistics Core
Jonathan D. Mahnken, PhD
Hung-Wen (Henry) Yeh, PhD
Russ Waitman, PhD
Bhargav Adagarla, MS
Suzanne Hunt, MS
Cathy Price, BS
Mani Nair, MS, MBA
Megan Parks, AA
Dan Connolly, BS
Alexandra Brown, BS
Neuropathology Core
Kathy Newell, MD
Cynthia Gouvion
Neuroimaging Core
William Brooks, PhD
In-Young Choi, PhD, MR
Phil Lee, PhD, MR
Laura Martin, PhD
Cary Savage, PhD
Reg Dusing, MD
How to Contact KU ADC
KU Alzheimer’s Disease Center
(913) 588-0555
[email protected]
www.kualzheimer.org
Research Requests
http://www.kualzheimers.org/alzheimers-diseasecenter/researcher-resources/researcher-resource-request.html
Data Core
http://biostatistics.kumc.edu